| Type | Description |
|---|---|
| Definition | olf186-F |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 12:09:00 | using a gain-of-function mutation that constitutively activates the channel, we present an X-ray structure of Drosophila melanogaster Orai in an open conformation. Well-defined electron density maps reveal that the pore is dramatically dilated on its cytosolic side in comparison to the slender closed pore. | 30160233 |
| 2017-11-04 12:42:00 | Ca2+ uptake in neurons with reduced SEPT7 requires Orai. | 27225060 |
| 2017-08-05 10:55:00 | after depletion of Ca(2+) stores in Drosophila, translocation of the IP3R to Endoplasmic reticulum-plasma-membrane junctions facilitates the coupling of STIM to Orai that leads to activation of Store-operated Ca(2+) entry. | 27591258 |
| 2016-01-16 11:59:00 | These studies suggest that modulation of SOCE could serve as a novel mechanism for restoring dopamine levels in dopaminergic neurons. | 26446229 |
| 2013-09-21 13:15:00 | Data indicate that STIM functions as sensors of Ca2+ stored in the endoplasmic reticulum (ER) lumen and translocate into ER-PM (plasma membrane) junctions to tether and activate Orai channels when ER Ca2+ concentration decreases. | 23512988 |
| Type | IDs |
|---|---|
| Synonymous | BcDNA:LD03241, CG11430, CRACM1, DOrai, Dmel\CG11430, Olf186-F, Orai, Orai1, SPH206, dOrai, dOrai1, dorai, l(2)k11505, orai |
| Gene |
UniProtKB-ID:
CRCM1_DROME,
E2QCH2_DROME
UniprotKB:
Q9U6B8,
E2QCH2
UniParc:
UPI000000C0A9,
UPI00000851A3,
UPI000007C86D
EMBL:
BT003591,
AY071273,
AE013599,
AF188634,
BT001876,
DQ503470
EnsemblGenome:
FBgn0041585
KO:
dme:Dmel_CG11430
|
| Nucleutide sequences |
EMBL-CDS:
AAS64814.2,
ABF54966.1,
AAL48895.1,
AAF01457.1,
AGB93595.1,
AAO39594.1,
ACL83150.1,
AAF57780.2,
AAN71648.1,
AAM68473.1
Gene_ORFName:
CG11430,
CG11430,
Dmel_CG11430
EnsemblGenome_TRS:
FBtr0114614,
FBtr0336699,
FBtr0086795,
FBtr0086797,
FBtr0336698,
FBtr0086797,
FBtr0086795,
FBtr0336698
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0085974,
FBpp0085976,
FBpp0113106,
FBpp0307679,
FBpp0307680,
FBpp0085974,
FBpp0085976,
FBpp0307679
RefSeq:
NP_611273.1,
NP_001137696.1,
NP_001261063.1,
NP_995881.2,
NP_725727.1
|
| Others |
UniRef100:
UniRef100_Q9U6B8
UniRef90:
UniRef90_Q9U6B8
UniRef50:
UniRef50_Q9U6B8
UniGene:
Dm.7627
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员