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3700 ITIH4

3700

ITIH4

inter-alpha-trypsin inhibitor heavy chain family member 4

protein-coding

Homo sapiens

基因描述

Type Description
Definition inter-alpha-trypsin inhibitor heavy chain family member 4

研究结论

Date Results Publications
2020-04-18 10:58:00 sgp120 or ITIH4 is cleaved when the contact system is activated and this cleavage could be used as a biomarker in patients with hereditary angioedema with normal C1 inhibitor 31955064
2019-11-16 12:14:00 ITIH4 SNPs rs3821831 and rs2239547 were studied in pregnant depressed Japanese women. Compared with the TT genotype of ITIH4 SNP rs2239547, the CC genotype was significantly related to a reduced risk of depressive symptoms during pregnancy. SNP rs3821831 was not related to these symptoms.The GCCT haplotype of rs2535629, rs736408, rs3821831, and rs2239547 was significantly positively associated with depressive symptoms. 29992445
2019-03-16 12:47:00 The ITI-H4 (N(688)) might be a crucial inflammatory factor which contributes to the pathogenesis of recurrent pregnancy loss (RPL). Moreover, it is expected that this study would give some insights into potential functional mechanisms underlying RPL. 30348621
2018-10-27 10:41:00 Low ITIH4 expression is associated with Hepatocellular Carcinoma. 28828637
2017-01-14 10:52:00 this report has further supported for associations of genetic variants in the ITIH4 and CALN1 genes with schizophrenia and provided the first evidence that the variants regulate ITIH4 AND CALN1 expression in the dorsolateral prefrontal cortex 26991396

名称对应

Type IDs
Synonymous GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120
Gene
UniProtKB-ID: ITIH4_HUMAN, B7ZKJ8_HUMAN, B2RMS9_HUMAN
UniprotKB: Q14624, B7ZKJ8, B2RMS9
UniParc: UPI000020AD55, UPI000020AD4C, UPI00029CD9A7, UPI00017479B5, UPI000189A774, UPI000013D6C3
EMBL: AK298412, U43157, U43155, KC876888, U42016, U43162, U43158, AF119856, D38595, BC136393, U43156, U43163, AC006254, U43159, U43161, D38535, AC099667, U43160, U42015, BC136392
Ensembl: ENSG00000055955
KO: hsa:3700
Nucleutide sequences
EMBL-CDS: BAH12781.1, AAD05198.1, AAF69610.1, BAA07536.1, BAA07602.1, AAI36393.1, AAI36394.1
Gene_ORFName: PRO1851
Ensembl_TRS: ENST00000406595, ENST00000266041, ENST00000485816
Protein sequencees
Ensembl_PRO: ENSP00000384425, ENSP00000266041, ENSP00000417824
RefSeq: NP_002209.2, NP_001159921.1
Others
UniRef100: UniRef100_Q14624, UniRef100_B7ZKJ8, UniRef100_B2RMS9
UniRef90: UniRef90_Q14624
UniRef50: UniRef50_Q14624
UniGene: Hs.709406
CCDS: CCDS54596.1, CCDS2865.1

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