| Type | Description |
|---|---|
| Definition | SMAD specific E3 ubiquitin protein ligase |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 11:01:00 | Data show that hedgehog (Hh)-induced phosphorylation of signal transducer Smoothened (Smo) inhibits smurf E3 ligase (Smurf) recruitment to Smo. | 29438012 |
| 2018-12-22 12:13:00 | dSmurf is required for synapse remodeling and axon pruning by glia | 28057437 |
| 2017-07-15 12:12:00 | Together, our results demonstrate that transcriptional repression of Ed followed by Smurf-mediated downregulation of pretranslated Ed in amnioserosa regulates the establishment of a taut leading edge during dorsal closure | 28428287 |
| 2017-05-27 11:04:00 | Interaction with Slimb leads to the ubiquitination and degradation of dSmurf, resulting in negative regulation of dSmurf-mediated Yki phosphorylation and activity in the Hippo pathway. Thus our study revealed a new regulatory mechanism of the Hippo pathway which may provide implications for developing tumor treatment. | 27856247 |
| 2015-05-02 10:05:00 | Sufficient knock-down of dSmurf increases the protein abundance of Wts and thus increases phosphorylation level at S168 of Yki, the key downstream target of Wts in the Hippo pathway. | 25450375 |
| Type | IDs |
|---|---|
| Synonymous | CG4943, D-smurf, DSmurf, Dmel\CG4943, Dsmurf, LACK, Lack, SMURF, Smurf ubiquitin ligase, d-smurf, dSmurf, dSmurf1, lack, smurf |
| Gene |
UniProtKB-ID:
SMUF1_DROME,
A0A0B4KFU5_DROME
UniprotKB:
Q9V853,
A0A0B4KFU5
UniParc:
UPI000007B10E
EMBL:
AE013599,
AF416571,
AF216521,
AF464851,
BT021410
EnsemblGenome:
FBgn0029006
KO:
dme:Dmel_CG4943
|
| Nucleutide sequences |
EMBL-CDS:
AAX33558.1,
AAM09646.1,
AAL09691.1,
AAF57824.3,
AAF21125.1,
AGB93593.1
Gene_ORFName:
CG4943,
CG4943,
Dmel_CG4943
EnsemblGenome_TRS:
FBtr0333168,
FBtr0086833,
FBtr0086833,
FBtr0333168
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0086011,
FBpp0305371,
FBpp0305371,
FBpp0086011
RefSeq:
NP_001261061.1,
NP_523779.1
|
| Others |
UniRef100:
UniRef100_Q9V853
UniRef90:
UniRef90_Q9V853
UniRef50:
UniRef50_Q9V853
UniGene:
Dm.2783
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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