| Type | Description |
|---|---|
| Definition | inter-alpha-trypsin inhibitor heavy chain 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:30:00 | Both IalphaI and the HC-hyaluronan complex are substrates for the extracellular matrix proteases ADAMTS-5 and matrix metalloprotease (MMP) -3, -7, and -13. | 31484722 |
| 2016-08-06 11:59:00 | Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. | 26728454 |
| 2012-12-22 11:16:00 | Human inter-alpha-inhibitor is a substrate for factor XIIIa and tissue transglutaminase. | 21939789 |
| 2010-05-31 11:24:00 | It forms complex with hyaluronan and the comlex is a functional molecule involved in inflammation. | 20297716 |
| 2010-01-21 00:00:00 | TSG-6 acts as cofactor and catalyst in the production of IalphaI heavy chain x hyaluronan complexes | 15840581 |
| Type | IDs |
|---|---|
| Synonymous | H2P, SHAP |
| Gene |
UniProtKB-ID:
ITIH2_HUMAN
UniprotKB:
P19823
UniParc:
UPI000036665E
EMBL:
M18193,
M33033,
X07173,
AL158044
Ensembl:
ENSG00000151655
KO:
hsa:3698
|
| Nucleutide sequences |
EMBL-CDS:
CAA30160.1,
AAA60558.1,
AAA59195.1
Ensembl_TRS:
ENST00000358415
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000351190
RefSeq:
NP_002207.2
|
| Others |
UniRef100:
UniRef100_P19823
UniRef90:
UniRef90_P19823
UniRef50:
UniRef50_P19823
UniGene:
Hs.75285
CCDS:
CCDS31141.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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