| Type | Description |
|---|---|
| Definition | inter-alpha-trypsin inhibitor heavy chain 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:30:00 | Both IalphaI and the HC-hyaluronan complex are substrates for the extracellular matrix proteases ADAMTS-5 and matrix metalloprotease (MMP) -3, -7, and -13. | 31484722 |
| 2017-05-27 11:43:00 | Furthermore, thrombin treatment of the inflammatory matrix leads to dissolution of HC-HA cable structures and abolishes leukocyte adhesion. These data establish a novel mechanism whereby thrombin cleavage of HC1 regulates the adhesive properties of an inflammatory HA matrix. | 27679489 |
| 2016-08-06 11:59:00 | Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. | 26728454 |
| 2014-11-29 11:27:00 | The results of this study revealed that the shared genetic risk factors of both schizophrenia and major depressive disorder exist in ITIH family genes in the Han Chinese population. | 24389398 |
| 2013-12-14 11:52:00 | Data indicate that TSG-6-mediated cross-linking of hyaluronan (HA) films is impaired in the presence of inter-alpha-inhibitor (IalphaI) and that this effect suppresses the TSG-6-mediated enhancement of HA binding to CD44-positive cells. | 24005673 |
| Type | IDs |
|---|---|
| Synonymous | H1P, IATIH, IGHEP1, ITI-HC1, ITIH, SHAP |
| Gene |
UniProtKB-ID:
ITIH1_HUMAN,
B7Z8B6_HUMAN
UniprotKB:
P19827,
B7Z8B6
UniParc:
UPI0001BAC46E,
UPI000012DA1C,
UPI0001BAC46D,
UPI0001915276
EMBL:
M18192,
AC006254,
X69544,
X69536,
X69532,
AK303110,
X69540,
AK298455,
X69535,
X69538,
X69537,
X69539,
X69541,
X75318,
X69533,
X69534,
CH471055,
X69545,
BC069464,
X69543,
AK314198,
AK303156,
X63652,
X69547,
X69542,
X16260,
X69546,
AK292750
Ensembl:
ENSG00000055957
KO:
hsa:3697
|
| Nucleutide sequences |
EMBL-CDS:
CAA34346.1,
CAA45188.1,
BAH13906.1,
BAF85439.1,
EAW65259.1,
AAH69464.1,
BAH12794.1,
AAA60557.1,
CAA53067.1,
CAA49279.1,
BAG36876.1,
BAH13902.1
Ensembl_TRS:
ENST00000273283,
ENST00000537050
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000273283,
ENSP00000443847
RefSeq:
NP_001159907.1,
NP_001159906.1,
NP_001159908.1,
NP_002206.2
|
| Others |
UniRef100:
UniRef100_B7Z8B6,
UniRef100_P19827
UniRef90:
UniRef90_P19827,
UniRef90_B7Z8B6
UniRef50:
UniRef50_A0A3Q7RJ38,
UniRef50_P19827
UniGene:
Hs.76716,
Hs.420257
CCDS:
CCDS54595.1,
CCDS2864.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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