| Type | Description |
|---|---|
| Definition | Lethal hybrid rescue |
| Date | Results | Publications |
|---|---|---|
| 2018-07-21 11:27:00 | We conclude that there is no evidence for a centromeric function of Hmr and Lhr within D. melanogaster nor for a centromere defect causing hybrid lethality. Instead, we find that Hmr and Lhr are required in D. melanogaster for detachment of sister chromatids during anaphase. | 29046402 |
| 2014-11-29 10:38:00 | Using RNA-Seq analyses we discovered that Hmr and Lhr are required to repress transcripts from satellite DNAs and many families of transposable elements (TEs). | 24651406 |
| 2014-11-08 12:09:00 | Results are consistent with the allelic asymmetry model of the Lhr gene expression in the hybrid. | 24379167 |
| 2011-06-18 10:56:00 | LHR orthologs interact with HP1 and HP6, and can localize to heterochromatin when expressed in D. melanogaster. | 21366928 |
| 2010-01-21 00:00:00 | findings show Lhr has functionally diverged in D. simulans & interacts with Hybrid male rescue, which has functionally diverged in D. melanogaster, to cause lethality in F1 hybrid males; LHR has diverged in these species consistent with positive selection | 17124320 |
| Type | IDs |
|---|---|
| Synonymous | CG18468, Dmel\CG18468, HP3, LHR, LHR[[mel]], mel-Lhr |
| Gene |
UniProtKB-ID:
Q95RV3_DROME
UniprotKB:
Q95RV3
UniParc:
UPI00000076DA
EMBL:
AE013599,
AY061112
EnsemblGenome:
FBgn0034217
KO:
dme:Dmel_CG18468
|
| Nucleutide sequences |
EMBL-CDS:
AAL28660.1,
AAF57867.2
Gene_ORFName:
CG18468,
Dmel_CG18468
EnsemblGenome_TRS:
FBtr0086917
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0086073
RefSeq:
NP_611210.3
|
| Others |
UniRef100:
UniRef100_Q95RV3
UniRef90:
UniRef90_Q95RV3
UniRef50:
UniRef50_Q95RV3
UniGene:
Dm.3715
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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