| Type | Description |
|---|---|
| Definition | Death-associated APAF1-related killer |
| Date | Results | Publications |
|---|---|---|
| 2017-10-21 10:33:00 | Study presents a structure of the Dark apoptosome at 4.4 A degrees resolution. A nearly complete atomic model clarifies dATP selectivity during nucleotide exchange, suggests a role for the b-propellers in assembly, and provides a framework to understand apical procaspase activation. | 27916517 |
| 2010-01-21 00:00:00 | polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis | 15590702 |
| 2010-01-21 00:00:00 | ARK is essential for apoptosis during D. melanogaster development, and for radiation-induced apoptosis. Ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged. | 16533943 |
| 2010-01-21 00:00:00 | structural analysis of Apaf-1 in the auto-inhibited form demonstrates the critical role of ADP [review] | 15970665 |
| 2010-01-21 00:00:00 | identified helical domain I in the nucleotide oligomerization domain as critical for ARK's apoptotic activity. | 16645639 |
| Type | IDs |
|---|---|
| Synonymous | APAF-1, APAF1, ARK, Apaf, Apaf-1, Apaf1, Ark, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dApaf-1, Dark/Hac-1/dApaf1, Dmel\CG6829, Hac-1, Hac-1/Dark, Hac1, T1, anon-53Fa, apaf-1, apaf1, arc, ark, dAPAF-1, dApaf-1, dApaf-1/DARK/HAC-1, dApaf1, dArk, dapaf, dapaf-1, dapaf-1L, dapaf-1S, dark, dark/dapaf-1/hac-1, dark/hac-1/dapaf-1, hac-1, hac1, l(2)SH0173 |
| Gene |
UniProtKB-ID:
Q9U8R4_DROME,
Q7KLI1_DROME
UniprotKB:
Q9U8R4,
Q7KLI1
UniParc:
UPI00000822B1,
UPI000007D6F2
EMBL:
AB027531,
AB027532,
AE013599,
AF162659,
AF196306,
BT150397
EnsemblGenome:
FBgn0263864
KO:
dme:Dmel_CG6829
|
| Nucleutide sequences |
EMBL-CDS:
AAM68488.1,
BAA86940.1,
AAD45988.1,
AAF07207.2,
AAF57916.1,
BAA86939.1,
AHA95701.1
Gene_ORFName:
CG6829,
Dmel_CG6829,
CG6829,
Dmel_CG6829
EnsemblGenome_TRS:
FBtr0086967,
FBtr0086968
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0086121,
FBpp0086122
RefSeq:
NP_725638.1,
NP_725637.1
|
| Others |
UniRef100:
UniRef100_Q9U8R4,
UniRef100_Q7KLI1
UniRef90:
UniRef90_Q7KLI1,
UniRef90_Q9U8R4
UniRef50:
UniRef50_Q9U8R4,
UniRef50_Q7KLI1
UniGene:
Dm.3047
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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