| Type | Description |
|---|---|
| Definition | Dopamine transporter |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 11:14:00 | Study identified Na+- and dopamine-induced changes in specific regions of the wild-type Drosophila melanogaster dopamine transporter, suggesting their involvement in protein conformational transitions. Ligand-dependent slow cooperative fluctuations of helical stretches in several domains of the transporter were detected, which could be a molecular mechanism that assists in the transporter function. | 31221956 |
| 2016-11-12 11:53:00 | When DAT, a member of the post-feeding reward system, is either overexpressed or reduced via mutation, Drosophila has increased sensitivity to amino acid starvation. | 26909968 |
| 2015-07-04 12:12:00 | X-ray crystal structures of dopamine transporter (DAT) bound to its substrate dopamine, a substrate analogue 3,4-dichlorophenethylamine, the psychostimulants d-amphetamine and methamphetamine, or to cocaine and cocaine analogues | 25970245 |
| 2014-08-09 12:27:00 | Phosphatidylinositol-4,5-Biphosphate regulates psychostimulant behaviors through its interaction with a membrane dopamine transporter. | 24880859 |
| 2013-12-14 12:33:00 | the dopamine transporter X ray structure reveals the molecular basis for antidepressant action on sodium-coupled neurotransmitter symporters and elucidates critical elements of eukaryotic transporter structure and modulation by lipids | 24037379 |
| Type | IDs |
|---|---|
| Synonymous | CG8380, DmDAT, Dmel\CG8380, dDAT, dat, fmn, fumin |
| Gene |
UniProtKB-ID:
DAT_DROME,
A0A0B4KEX2_DROME
UniprotKB:
Q7K4Y6,
A0A0B4KEX2
UniParc:
UPI000007A6E7,
UPI00029428E6
EMBL:
AY051579,
AF260833,
AF439752,
AE013599
EnsemblGenome:
FBgn0034136
KO:
dme:Dmel_CG8380
|
| Nucleutide sequences |
EMBL-CDS:
AAK93003.1,
AAF57986.2,
AAF76882.1,
AAL32055.1,
AGB93558.1
Gene_ORFName:
CG8380,
Dmel_CG8380,
CG8380
EnsemblGenome_TRS:
FBtr0087125,
FBtr0330002
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0086271,
FBpp0303037
RefSeq:
NP_523763.2,
NP_001261026.1
|
| Others |
UniRef100:
UniRef100_Q7K4Y6
UniRef90:
UniRef90_Q7K4Y6
UniRef50:
UniRef50_Q7K4Y6
UniGene:
Dm.2848
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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