Aph1a - aph-1 homolog A, gamma secretase subunit-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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365872 Aph1a

基因描述

Type	Description
Definition	aph-1 homolog A, gamma secretase subunit

研究结论

Date	Results	Publications
2010-05-10 12:12:00	Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates	20145246
2010-01-21 00:00:00	Nicastrin, presenilin 1, APH-1, and PEN-2 form an active gamma-secretase complex expressed in mitochondria.	15456764

名称对应

Type	IDs
Synonymous	RGD1311546
Gene	UniProtKB-ID: A0A0G2K6H8_RAT, Q5PQQ3_RAT UniprotKB: A0A0G2K6H8, Q5PQQ3 UniParc: UPI00001CEF18, UPI0000496718 EMBL: CH474015, AC141102, BC087081 Ensembl: ENSRNOG00000023816 KO: rno:365872
Nucleutide sequences	EMBL-CDS: EDL85667.1, EDL85668.1, AAH87081.1 Gene_ORFName: rCG_52020, rCG_52020 Ensembl_TRS: ENSRNOT00000081383, ENSRNOT00000056289
Protein sequencees	Ensembl_PRO: ENSRNOP00000073820, ENSRNOP00000053129 RefSeq: NP_001014277.1, XP_006233039.1
Others	UniRef100: UniRef100_Q5PQQ3, UniRef100_A0A0G2K6H8 UniRef90: UniRef90_Q8BVF7, UniRef90_Q5PQQ3 UniRef50: UniRef50_Q96BI3, UniRef50_Q5PQQ3 UniGene: Rn.22786

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
28588301	Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer's disease: emphasis on inhibition of Î²-amyloid, COX-2, alpha-, beta - secretases and APH1a. Sci Rep Ali M El Halawany , Nesrine S El Sayed , Hossam M Abdallah , Riham Salah El Dine	2017-06-06	-
29926633	[Effect of Î²sheet blocking peptide H102 on APP metabolic enzymes in hippocampal brain of double transgenic AD mice]. Zhongguo Ying Yong Sheng Li Xue Za Zhi Fang Jiang , Feng-Xian Sun , Shu-Mei Xu	2017-04-08	-
26280335	An atomic structure of human Î³-secretase. Nature Xiao-Chen Bai , Chuangye Yan , Guanghui Yang , Peilong Lu , Dan Ma , Linfeng Sun , Rui Zhou , Sjors H W Scheres , Yigong Shi	2015-09-10	-
25043039	Three-dimensional structure of human Î³-secretase. Nature Peilong Lu , Xiao-Chen Bai , Dan Ma , Tian Xie , Chuangye Yan , Linfeng Sun , Guanghui Yang , Yanyu Zhao , Rui Zhou , Sjors H W Scheres , Yigong Shi	2014-08-14	-
22771797	Erlin-2 is associated with active Î³-secretase in brain and affects amyloid Î²-peptide production. Biochem. Biophys. Res. Commun. Yasuhiro Teranishi , Ji-Yeun Hur , Gucci Jijuan Gu , Takahiro Kihara , Taizo Ishikawa , Takeshi Nishimura , Bengt Winblad , Homira Behbahani , Masood Kamali-Moghaddam , Susanne Frykman , Lars O Tjernberg	2012-08-03	Psen1, Erlin2, Ncstn, Erlin2, Psen1, Psenen, Aph1a, ERLIN2, NCSTN, APH1A, PSENEN, PSEN1
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
20145246	Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J Biol Chem Allen C Chen , Lucie Y Guo , Beth L Ostaszewski , Dennis J Selkoe , Matthew J LaVoie	2010-04-09	-
20130175	Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci Guojun Zhao , Zhenyi Liu , Ma Xenia G Ilagan , Raphael Kopan	2010-02-03	-
19946888	Defining the membrane proteome of NK cells. J Mass Spectrom Dhimankrishna Ghosh , Dustin Lippert , Oleg Krokhin , John P Cortens , John A Wilkins	2010-01-01	MED6, PDCD6IP, MED16, PIGK, DNAJB6, FARSB, DNM1L, ABCF2, HUWE1, ARPC3, ACTR3, ACTR2, RAD50, PREB, ACTR1B, LRPPRC, TRAP1, BCAP31, PLXNC1, LPCAT3, TNK2, PSME3, MPHOSPH9, FLOT1, DDX39A, AK6, ADAM10, PLIN3, CALCOCO2, CDK9, ABCC4, ZMPSTE24, AKAP8, BET1, MARCH6, KATNB1, ADAR, EMC8, BTN3A3, ATP8A1, NDC80, CDIPT, PGRMC2, TUBGCP3, ECI2, COG5, SLC25A17, LRRC41, SYNCRIP, MYBBP1A, DDX17, CHERP, HYOU1, IPO7, NOP56, ARL6IP5, HTATIP2, AGPAT1, ARFGEF2, RABAC1, SLU7, PRPF8, PAICS, CENPE, PMVK, KHDRBS1, CELF1, GNA13, CFL1, MGEA5, YME1L1, STAG2, CTSC, GIPC1, HBS1L, TUBGCP2, PGRMC1, MAN1A2, PNPLA6, MAGED2, ADCY3, EHD1, TOMM34, ERP29, YWHAQ, ASCC3, GCN1, IMMT, ILVBL, SLC27A4, SLC27A3, KIF2C, GLIPR1, CPSF6, DDX52, WWP2, CNTRL, CHD4, KRR1
20126630	Synaptic and endosomal localization of active gamma-secretase in rat brain. PLoS ONE Susanne Frykman , Ji-Yeun Hur , Jenny FrÃ¥nberg , Mikio Aoki , Bengt Winblad , Jarmila Nahalkova , Homira Behbahani , Lars O Tjernberg	2010-01-01	-

研究热度

热点单位

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