| Type | Description |
|---|---|
| Definition | iron responsive element binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:55:00 | Mdm2 is a target and mediator of IRP2 in cell growth control. | 31907996 |
| 2020-07-25 12:44:00 | This study has identified an iron-sulfur cluster within FBXL5, which promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations. | 32126207 |
| 2020-02-29 11:31:00 | To better understand the mechanisms of zinc-induced iron absorption, we have studied the effect of zinc on iron uptake, iron transporter and iron regulatory protein (IRP 1 and 2) expression and the impact of the PI3K pathway in differentiated Caco-2 cells, an intestinal cell culture model. We found that zinc induces DMT1 protein and mRNA expression. | 31092704 |
| 2020-02-01 11:27:00 | Ectopic expression of IRP2 suppressed cell growth in a mutant p53-dependent manner. Together, these data indicate that mutant p53 gain-of-function can be suppressed by IRP2 and Ferredoxin reductase deficiency, both of which may be explored to target tumors carrying mutant p53. | 31332290 |
| 2019-02-16 10:34:00 | All four variants were significantly associated (P < 1.4 x 10(-6)) with blood DNA methylation of IREB2, CHRNA3 and PSMA4, of which two, including IREB2 and PSMA4, were also differentially methylated in Chronic obstructive pulmonary disease cases and controls | 29422661 |
| Type | IDs |
|---|---|
| Synonymous | ACO3, IRE-BP 2, IRE-BP2, IRP2, IRP2AD |
| Gene |
UniProtKB-ID:
IREB2_HUMAN,
D3DW85_HUMAN
UniprotKB:
P48200,
D3DW85
UniParc:
UPI0004620DD2,
UPI000034ECAD,
UPI000006FEBD
EMBL:
BC117481,
AL133439,
AC027228,
BC117483,
BC017880,
AB209403,
KF459563,
DQ496102,
CH471136,
AB586699,
M58511,
AC011270,
U20180,
AK292992
Ensembl:
ENSG00000136381
KO:
hsa:3658
|
| Nucleutide sequences |
EMBL-CDS:
AAI17484.1,
AAA69901.1,
AAH17880.1,
AAI17482.1,
CAB62825.1,
BAF85681.1,
ABF47091.1,
BAD92640.1,
EAW99169.1,
AAA79926.1,
BAJ19024.1,
EAW99170.1
Gene_ORFName:
hCG_38938
Ensembl_TRS:
ENST00000258886,
ENST00000560440
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000258886,
ENSP00000452938
RefSeq:
NP_004127.2,
NP_001307872.1,
NP_001307870.2,
NP_001341923.2,
NP_001307871.2
|
| Others |
UniRef100:
UniRef100_D3DW85,
UniRef100_P48200
UniRef90:
UniRef90_P48200
UniRef50:
UniRef50_P21399
UniGene:
Hs.436031
CCDS:
CCDS10302.1,
CCDS81912.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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