| Type | Description |
|---|---|
| Definition | polymerase |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 16:03:00 | Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A. | 32694517 |
| 2018-12-01 11:24:00 | Substitution of the influenza-virus polymerase basic protein 2 (PB2) gene segment of the H5N8 virus by that from the H5N1 virus results in a increased virulence for mice compared with the parental virus. The reassortant virus also induced the highest virus titers in lungs and the highest levels of inflammatory cytokine responses. | 28873012 |
| 2018-06-16 11:12:00 | Two miRNAs, miR-584-5p and miR-1249, that matched with the PB2 binding sequence, dramatically down-regulated PB2 expression, and inhibited replication of H5N1 and H1N1 influenza A virus strains in A549 cells. | 28609011 |
| 2018-02-24 10:30:00 | Using NMR chemical shift perturbation assays we show that amino acid region 601 to 607 of the PB2 '627' domain interacts with a fragment of NP. Substitutions of these PB2 amino acids resulted in diminished RNP activity and surface plasmon resonance assays showed that amino acids D605 was essential for the interaction with NP and V606 may also play a partial role in the interaction. | 29338047 |
| 2015-11-21 11:33:00 | PB2-K526R interacts with nuclear export protein and our results suggest that it contributes to enhance replication for certain influenza virus subtypes, particularly in combination with 627K. | 25409547 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PB2_I96A0
UniprotKB:
Q9Q0V1
UniParc:
UPI00000F6115
EMBL:
AF144300
KO:
vg:3654615
|
| Nucleutide sequences |
EMBL-CDS:
AAD51922.1
|
| Protein sequencees |
RefSeq:
YP_308664.1
|
| Others |
UniRef100:
UniRef100_Q9Q0V1
UniRef90:
UniRef90_P03427
UniRef50:
UniRef50_P03427
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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