| Type | Description |
|---|---|
| Definition | insulin receptor related receptor |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:28:00 | Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies. | 32708676 |
| 2020-06-13 12:23:00 | ectoIRR's sensing of alkaline conditions involves additional molecular mechanisms, for example engagement of receptor juxtamembrane regions or the surrounding lipid environment. | 31615897 |
| 2018-08-18 10:12:00 | the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain. | 29156593 |
| 2015-12-05 11:20:00 | IRR activation involves two separate centers of pH-dependent rearrangements that act synergistically to induce a major conformational change in the IRR molecule, resulting in internal kinase domains rapprochement and autophosphorylation. | 25597417 |
| 2014-02-08 12:25:00 | IRR activation is not based on a single residue deprotonation in the IRR ectodomain but rather involves synergistic conformational changes at multiple points. | 24121506 |
| Type | IDs |
|---|---|
| Synonymous | IRR |
| Gene |
UniProtKB-ID:
INSRR_HUMAN
UniprotKB:
P14616
UniParc:
UPI000012D8BD
EMBL:
J05046,
AL158169,
AF064078,
CH471121
Ensembl:
ENSG00000027644
KO:
hsa:3645
|
| Nucleutide sequences |
EMBL-CDS:
AAC31759.1,
AAC17167.1,
EAW52903.1
Ensembl_TRS:
ENST00000368195
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000357178
RefSeq:
NP_055030.1
|
| Others |
UniRef100:
UniRef100_P14616
UniRef90:
UniRef90_P14616
UniRef50:
UniRef50_P14616
UniGene:
Hs.248138
CCDS:
CCDS1160.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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