| Type | Description |
|---|---|
| Definition | sterol 14-demethylase |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 12:37:00 | Deletion of (sterol 14-demethylase) ERG11 in Candida albicans reduces filamentous and invasive growth, and impairs hyphal elongation in sensing serum. Lack of ERG11 increases susceptibility to H2O2 and is defective in clearing reactive oxygen species. C. albicans cells lacking ERG11 are more efficiently killed by macrophages and become avirulent in vivo. | 29931064 |
| 2019-05-18 10:10:00 | Antifungal drug resistance mutations in Candida albicans lanosterol 14alpha-demethylase have been reported using genetic complementation tests in Saccharomyces cerevisiae. | 29263059 |
| 2018-05-19 11:17:00 | A newly identified amino acid substitution threonine123isoleucine in the 14alpha-demethylase (Erg11p) of Candida albicans confers azole resistance. | 28334124 |
| 2018-03-31 10:03:00 | Overexpressed ERG4 and ERG11 genes are found in azole-resistant C. albicans isolates; the mRNA levels of ERG4 may be irrelevant to ERG11 in resistant C. albicans isolates. | 27976986 |
| 2016-12-17 11:14:00 | study identified 14 different missense mutations, five of which had not been described previously; the L321F mutation in C. albicans ERG11 gene may be associated with fluconazole resistance | 23402828 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
CP51_CANAL
UniprotKB:
P10613
UniParc:
UPI00001281E5
EMBL:
EU819548,
U67192,
EU819551,
FJ002303,
CP017627,
X13296,
FJ403378,
U67193
KO:
cal:CAALFM_C500660CA
|
| Nucleutide sequences |
EMBL-CDS:
ACH91036.1,
ACF34639.1,
AAB08099.1,
CAA31658.1,
ACJ23064.1,
AAB08100.1,
ACF34636.1,
AOW29509.1
Gene_ORFName:
CaO19.922
|
| Protein sequencees |
RefSeq:
XP_716761.1
|
| Others |
UniRef100:
UniRef100_P10613
UniRef90:
UniRef90_P10613
UniRef50:
UniRef50_P10613
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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