| Type | Description |
|---|---|
| Definition | frazzled |
| Date | Results | Publications |
|---|---|---|
| 2018-07-14 12:15:00 | In disc-proper epithelial cells, Fra can affect localization of adherens junction components and columnar cell shape. 3 conserved cytoplasmic P-motifs are required. Protrusion formation required the P3 motif. Apico-basal cell shape change needed the P1 motif and was promoted by RhoGef2 but inhibited by Rac1. The loss of AJ proteins from basolateral regions of epithelial cells required all 3 P-motifs and depended on par6. | 29518139 |
| 2017-11-25 14:30:00 | Based on findings in other systems, we propose that adhesion to substrate-bound Net underlies both long- and short-range Net-Fra-dependent guidance in vivo, thereby eroding the distinction between them. | 27743477 |
| 2017-10-28 12:30:00 | Frazzled expression is induced by the transcription factor Glide/Gcm in a dose-dependent manner. | 27740455 |
| 2015-11-21 11:59:00 | Frazzled was found to have a role as a transcription factor whose activity regulates the responsiveness of commissural axons at the midline. | 26291159 |
| 2015-07-25 11:30:00 | Contact-mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development. | 25440577 |
| Type | IDs |
|---|---|
| Synonymous | CG8581, CT24981, DCC, Dmel\CG8581, Fra |
| Gene |
UniProtKB-ID:
A1Z920_DROME,
A0A0B4LEX6_DROME,
A1Z921_DROME
UniprotKB:
A1Z920,
A0A0B4LEX6,
A1Z921
UniParc:
UPI0002B8CDAD,
UPI0000075617,
UPI0000082ADD
EMBL:
BT150366,
AE013599
EnsemblGenome:
FBgn0011592
KO:
dme:Dmel_CG8581
|
| Nucleutide sequences |
EMBL-CDS:
AGW52176.1,
AAF58493.1,
AHN56151.1,
AAM68622.1
Gene_ORFName:
CG8581,
Dmel_CG8581,
CG8581,
Dmel_CG8581,
CG8581,
Dmel_CG8581
EnsemblGenome_TRS:
FBtr0087822,
FBtr0339649,
FBtr0087821
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0086935,
FBpp0308711,
FBpp0086934
RefSeq:
NP_001286353.1,
NP_725185.1,
NP_523716.2
|
| Others |
UniRef100:
UniRef100_A0A0B4LEX6,
UniRef100_A1Z921,
UniRef100_A1Z920
UniRef90:
UniRef90_A1Z920
UniRef50:
UniRef50_A1Z920
UniGene:
Dm.2428
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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