| Type | Description |
|---|---|
| Definition | insulin-like growth factor binding protein 4 |
| Date | Results | Publications |
|---|---|---|
| 2017-08-05 10:55:00 | IGFBP4 overexpression impaired BMP2-induced osteogenic differentiation potential of young MSCs, whereas IGFBP4 knockdown restored the osteogenic potency of aged MSCs. Moreover, IGFBP4 knockdown stimulated the activation of Erk and Smad by increasing phosphorylation. | 28595186 |
| 2015-08-10 16:03:00 | various inflammatory insults decrease muscle IGFBP-5 mRNA, without altering IGFBP-4, by a TNF-dependent glucocorticoid-independent mechanism. | 16339387 |
| 2014-04-12 11:27:00 | The temporal expression pattern of IGFBP-4 in the embryonic brain suggests an important role of IGFBP-4 in regulating differentiation of neural stem cells | 24175938 |
| 2013-08-31 12:04:00 | IGFBP-4 expression is induced in hepatoma cells by the dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). | 23639626 |
| 2012-01-14 11:58:00 | knockdown results in decreased differentiation potential of mesenchymal stromal cells | 21846294 |
| Type | IDs |
|---|---|
| Synonymous | IBP4, IGF-BP4 |
| Gene |
UniProtKB-ID:
IBP4_RAT
UniprotKB:
P21744
UniParc:
UPI000012D11B
EMBL:
AY686592,
L08276,
BC098750
Ensembl:
ENSRNOG00000010635
KO:
rno:360622
|
| Nucleutide sequences |
EMBL-CDS:
AAH98750.1,
AAT96376.1
Ensembl_TRS:
ENSRNOT00000014153
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000014153
RefSeq:
NP_001004274.1
|
| Others |
UniRef100:
UniRef100_P21744
UniRef90:
UniRef90_P47879
UniRef50:
UniRef50_P22692
UniGene:
Rn.160666
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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