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36040 TER94

36040

TER94

TER94

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition TER94

研究结论

Date Results Publications
2020-08-22 15:31:00 VCP Machinery Mediates Autophagic Degradation of Empty Argonaute. 31365860
2017-10-28 10:49:00 rescue experiments with a lethal mfap1 mutant show that the VCP binding region is not essential for Mfap1 function, but may act to increase its stability or activity 28837687
2017-07-29 11:25:00 Clu is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu-deficient flies and is destabilized upon Clu overexpression. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance. 26931463
2016-11-19 10:40:00 results have revealed SUMOylation as a molecular signaling switch to regulate the distribution and functions of VCP during stress response, and suggest that deficiency in VCP SUMOylation caused by pathogenic mutations will render cells vulnerable to stress insults. 27226613
2016-04-16 11:47:00 The authors propose that VCP sustains sarcoplasmic proteostasis, in part, by controlling the integrity of a dynamic tubular lysosomal network. 26167652

名称对应

Type IDs
Synonymous 22.26, 7.12, Apple, BcDNA.GM02885, BcDNA:GM02885, CDC48, CG2331, DmTER94, Dmel\CG2331, I, Q7KN62, Ter94, Tera, VCP, VCP ATPase, VCP/p97, Vcp, anon-WO2004063362.65, anon-WO2004063362.67, cdc48, dTERA, dVCP, dmTERA, dvcp, l(2)03775, l(2)46CFf, l(2)46CFs, l(2)46Ch, p97, pTER94, ter94, vcp
Gene
UniProtKB-ID: TERA_DROME, A0A0B4LFZ4_DROME
UniprotKB: Q7KN62, A0A0B4LFZ4
UniParc: UPI0000086694, UPI00015CFCDC, UPI000358FDB9, UPI00015CFCDB
EMBL: AF202034, AE013599, AF132553, AF047037
EnsemblGenome: FBgn0286784
KO: dme:Dmel_CG2331
Nucleutide sequences
EMBL-CDS: AAF58863.1, AAD27852.1, ABV53746.1, AAF17568.1, AAC27447.1, ABV53745.1, AHN56059.1
Gene_ORFName: CG2331, CG2331, Dmel_CG2331
EnsemblGenome_TRS: FBtr0088391, FBtr0112905, FBtr0112906, FBtr0343852
Protein sequencees
EnsemblGenome_PRO: FBpp0111818, FBpp0111819, FBpp0087479, FBpp0310395
RefSeq: NP_001097249.1, NP_001286261.1, NP_001097250.1, NP_477369.1
Others
UniRef100: UniRef100_Q7KN62, UniRef100_A0A0B4LFZ4
UniRef90: UniRef90_Q7KN62
UniRef50: UniRef50_P55072
UniGene: Dm.2968

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