Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.

Autophagy     Eleni N Tsakiri , Sentiljana Gumeni , Konstantinos Vougas , Diana Pendin , Issidora Papassideri , Andrea Daga , Vassilis Gorgoulis , Gábor Juhász , Luca Scorrano , Ioannis P Trougakos

Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis.

Sci Adv     Jia Zhou , Lingna Xu , Xiuying Duan , Wei Liu , Xiaocui Zhao , Xi Wang , Weina Shang , Xuefei Fang , Huan Yang , Lijun Jia , Jian Bai , Jiayao Zhao , Liquan Wang , Chao Tong

PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development.

Dev Cell     Kai Liu , Sandra Jones , Adi Minis , Jose Rodriguez , Henrik Molina , Hermann Steller

Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics.

Redox Biol     Sentiljana Gumeni , Zoi Evangelakou , Eleni N Tsakiri , Luca Scorrano , Ioannis P Trougakos

Protein-protein interaction network analysis of insecticide resistance molecular mechanism in Drosophila melanogaster.

Arch. Insect Biochem. Physiol.     GuiLu Zhang , WenJun Zhang

Alterations in Organismal Physiology, Impaired Stress Resistance, and Accelerated Aging in Drosophila Flies Adapted to Multigenerational Proteome Instability.

Oxid Med Cell Longev     Maria S Manola , Eleni N Tsakiri , Ioannis P Trougakos

TRF4, the novel TBP-related protein of Drosophila melanogaster, is concentrated at the endoplasmic reticulum and copurifies with proteins participating in the processes associated with endoplasmic reticulum.

J. Cell. Biochem.     Maria M Kurshakova , Elena N Nabirochkina , Sofia G Georgieva , Daria V Kopytova

Maternal Proteins That Are Phosphoregulated upon Egg Activation Include Crucial Factors for Oogenesis, Egg Activation and Embryogenesis in Drosophila melanogaster.

G3 (Bethesda)     Zijing Zhang , Amber R Krauchunas , Stephanie Huang , Mariana F Wolfner

Differential expression of Öbek controls ploidy in the Drosophila blood-brain barrier.

Development     Selen Zülbahar , Florian Sieglitz , Rita Kottmeier , Benjamin Altenhein , Sebastian Rumpf , Christian Klämbt

Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila.

Sci Rep     Jessica R Blount , Kozeta Libohova , Gregory B Marsh , Joanna R Sutton , Sokol V Todi