| Type | Description |
|---|---|
| Definition | interferon regulatory factor 2 binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 13:58:00 | Down-regulation of interferon regulatory factor 2 binding protein 2 suppresses gastric cancer progression by negatively regulating connective tissue growth factor. | 31559693 |
| 2020-02-08 11:40:00 | The expression of interferon regulatory protein 2-binding protein 2 (IRF2BP2), a regulator of KLF2, suppressed osteoclast differentiation and enhanced osteoblast differentiation and function. | 31186082 |
| 2019-09-07 11:17:00 | findings showed that the IRF2BP2-RARalpha fusion has the capacity to transform primary hematopoietic stem/progenitor cells and induced an ATRA-responsive acute promyelocytic leukemia (APL); this provides further evidence that formation of RARA fusion genes represent disease-defining mutations in APL pathogenesis | 27872498 |
| 2017-06-24 10:14:00 | A novel IRFBP2 mutation was identified in a family with autosomal dominant CVID. Transduction experiments suggest that the mutant protein has an effect on B-cell differentiation and is likely a monogenic cause of the family's CVID phenotype. | 27016798 |
| 2016-07-02 10:20:00 | ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation. | 26593974 |
| Type | IDs |
|---|---|
| Synonymous | CVID14 |
| Gene |
UniProtKB-ID:
I2BP2_HUMAN
UniprotKB:
Q7Z5L9
UniParc:
UPI000020608D,
UPI000004FA32,
UPI0000237C9C
EMBL:
BC065759,
AL160408,
BC020516,
AY278023,
AY278024
Ensembl:
ENSG00000168264
KO:
hsa:359948
|
| Nucleutide sequences |
EMBL-CDS:
AAH20516.1,
AAP78945.1,
AAP78944.1,
AAH65759.1
Ensembl_TRS:
ENST00000366609,
ENST00000366610
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000355568,
ENSP00000355569
RefSeq:
NP_001070865.1,
NP_892017.2
|
| Others |
UniRef100:
UniRef100_Q7Z5L9
UniRef90:
UniRef90_Q7Z5L9
UniRef50:
UniRef50_Q7Z5L9
UniGene:
Hs.350268
CCDS:
CCDS1602.1,
CCDS41475.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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