| Type | Description |
|---|---|
| Definition | COP9 signalosome subunit 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-16 11:13:00 | downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP | 30695029 |
| 2010-01-21 00:00:00 | we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway | 12737805 |
| 2010-01-21 00:00:00 | COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster. | 12223399 |
| 2010-01-21 00:00:00 | the CSN4 subunit of the COP9 signalosome co-occupies retinoblastoma target gene promoters with Rbf2 | 17251548 |
| Type | IDs |
|---|---|
| Synonymous | CG8725, CH4, Cops4, Csn4, DCH4, Dch4, Dmel\CG8725, csn4, l(2)k08018 |
| Gene |
UniProtKB-ID:
CSN4_DROME,
E1JH01_DROME
UniprotKB:
Q9V345,
E1JH01
UniParc:
UPI000000C4E4
EMBL:
BT004883,
AF129082,
AE013599
EnsemblGenome:
FBgn0027054
KO:
dme:Dmel_CG8725
|
| Nucleutide sequences |
EMBL-CDS:
AAO45239.1,
AAF59157.1,
AAD28607.1,
ACZ94359.1
Gene_ORFName:
CG8725,
Dmel_CG8725,
CG8725
EnsemblGenome_TRS:
FBtr0301230,
FBtr0088859,
FBtr0301230,
FBtr0088859
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0290448,
FBpp0087935,
FBpp0087935,
FBpp0290448
RefSeq:
NP_001163080.1,
NP_477444.1
|
| Others |
UniRef100:
UniRef100_Q9V345
UniRef90:
UniRef90_Q9V345
UniRef50:
UniRef50_Q9V345
UniGene:
Dm.3377
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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