| Type | Description |
|---|---|
| Definition | Src oncogene at 42A |
| Date | Results | Publications |
|---|---|---|
| 2019-03-02 10:48:00 | Suggest a model in which Src42A would sense the inherent anisotropic mechanical tension of the tracheal tube and translate it into a polarised Crumbs accumulation, which may promote a bias towards longitudinal membrane expansion, orienting cell elongation and, as a consequence, longitudinal growth at the tissue level. | 30475799 |
| 2018-10-20 11:47:00 | Src overexpression alone activated the Jun N-terminal Kinase (JNK) signalling pathway to promote actin cytoskeletal and cell polarity defects and drive apoptosis in in a whole epithelial tissue context in the Drosophila eye, whereas, in cooperation with RasACT, JNK led to a loss of differentiation and an invasive phenotype. | 29861494 |
| 2016-12-17 11:22:00 | show the same signaling occurs in Drosophila inflammatory cells in response to wound-induced H2O2 with mutants for the Lyn homolog Src42A displaying impaired inflammatory migration to wounds | 26028435 |
| 2016-04-09 10:20:00 | Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch-Src synergy. | 26222204 |
| 2015-10-10 10:27:00 | Reduction of Src42A function leads to nuclear translocation and activation of FOXO proteins. | 24513978 |
| Type | IDs |
|---|---|
| Synonymous | CG14471, CG44128, CG7873, DSrc42A, Dm SRC41, DmHD-29, Dmel\CG44128, Dmel_CG14471, Dmel_CG7873, Dsrc41, Dsrc42A, Dtk5, HD-29, SK2-4, SRC 42A, SRC42A, Src, Src41, Src42, Src42a, Su(D-raf)1, Su(Raf)1, Su(phl)1, Su1, Tk5, dSrc, dtk-5, dtk5, l(2)k10108, src, src42, src42A, src42a |
| Gene |
UniProtKB-ID:
SRC42_DROME,
B5X0J6_DROME,
A1Z6I9_DROME
UniprotKB:
Q9V9J3,
B5X0J6,
A1Z6I9
UniParc:
UPI0000086648,
UPI0002ADBD58
EMBL:
AE013599,
AJ002911,
BT044565,
S55977,
D42125,
AY058652
EnsemblGenome:
FBgn0264959
KO:
dme:Dmel_CG44128
|
| Nucleutide sequences |
EMBL-CDS:
AAF57295.1,
BAA07705.1,
AAL13881.1,
CAA05746.1,
AAB19907.1,
ACI15760.1,
AAM68338.2
Gene_ORFName:
CG44128,
Dmel_CG44128,
CG44128
EnsemblGenome_TRS:
FBtr0335275,
FBtr0335275,
FBtr0335276
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0307254,
FBpp0307254,
FBpp0307255
RefSeq:
NP_610191.2,
NP_476849.1
|
| Others |
UniRef100:
UniRef100_Q9V9J3,
UniRef100_A1Z6I9
UniRef90:
UniRef90_Q9V9J3,
UniRef90_A1Z6I9
UniRef50:
UniRef50_A1Z6I9,
UniRef50_Q9V9J3
UniGene:
Dm.4134
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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