| Type | Description |
|---|---|
| Definition | steppke |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:15:00 | This study is significant for defining a molecular mechanism that recruits Step to myosin-rich junctions for an established role in regulating actomyosin activity at these sites. | 31693432 |
| 2018-07-28 10:42:00 | In Drosophila, protein localization, laser ablation, and genetic interaction studies indicate that the cytohesin Steppke reduces tissue tension by inhibiting actomyosin activity at adherens junctions. Without Steppke, embryogenesis fails, with epidermal distortions and tears resulting from myosin misregulation. | 28736167 |
| 2016-05-28 10:22:00 | It is proposed that a global distribution of Step normally sets an inhibitory threshold for Rho1 activity to restrict early cell formation to the posterior. | 25971667 |
| 2014-07-12 12:50:00 | Steppke controls initial plasma membrane furrow ingression during the syncytial nuclear divisions and cellularization of the Drosophila embryo. Acting at the tips of ingressing furrows, Steppke promotes local endocytic events through its Arf-GEF activity. | 24120639 |
| 2013-11-16 10:23:00 | Step may be part of a larger signaling scaffold coordinating receptor tyrosine kinase-dependent MAPK activation | 23549788 |
| Type | IDs |
|---|---|
| Synonymous | CG11628, CG11633, CYH1, Dmel\CG11628, GPH, GRP1, GRP1/cytohesin 1, Grp1, Step, cytohesin/GRP1, l(2)SH0323, l(2)SH2 0323, l(2)k08110, stepk |
| Gene |
UniProtKB-ID:
Q9V9Q6_DROME,
Q0E8N2_DROME
UniprotKB:
Q9V9Q6,
Q0E8N2
UniParc:
UPI000008324E,
UPI0001BFFFA5
EMBL:
AE014134,
AY071322,
BT124891,
BT072836
EnsemblGenome:
FBgn0086779
KO:
dme:Dmel_CG11628
|
| Nucleutide sequences |
EMBL-CDS:
ACN63458.1,
AAF57230.2,
AAL48944.1,
AGB93213.1,
ABI31329.2,
ACZ94327.1,
ADG46059.1
Gene_ORFName:
CG11628,
Dmel_CG11628,
Dmel_CG11628,
CG11628
EnsemblGenome_TRS:
FBtr0085910,
FBtr0301616,
FBtr0332471,
FBtr0301617
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0085264,
FBpp0290831,
FBpp0304747,
FBpp0290832
RefSeq:
NP_001036375.2,
NP_001163041.1,
NP_610120.1,
NP_001260678.1
|
| Others |
UniRef100:
UniRef100_Q0E8N2,
UniRef100_Q9V9Q6
UniRef90:
UniRef90_Q0E8N2,
UniRef90_Q9V9Q6
UniRef50:
UniRef50_Q9V9Q6,
UniRef50_Q0E8N2
UniGene:
Dm.484
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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