| Type | Description |
|---|---|
| Definition | skywalker |
| Date | Results | Publications |
|---|---|---|
| 2017-05-20 10:44:00 | The crystal structure of the TBC domain of the Drosophila ortholog Skywalker, revealing an unanticipated cationic pocket conserved among TBC1D24 homologs. Cocrystallization and biochemistry showed that this pocket binds phosphoinositides phosphorylated at the 4 and 5 positions. The most prevalent patient mutations affect the phosphoinositide-binding pocket and inhibit lipid binding. | 27669036 |
| 2015-03-21 13:18:00 | this paper studies Drosophila melanogaster lacking active TBC1D24/Skywalker (Sky), a protein that in humans causes severe neurodegeneration, epilepsy, and DOOR (deafness, onychdystrophy, osteodystrophy, and mental retardation) syndrome, and identify endosome-to-lysosome trafficking as a mechanism for degradation of synaptic vesicle-associated proteins. | 25422373 |
| Type | IDs |
|---|---|
| Synonymous | CG14399, CG9339, CG9340, Dmel\CG9339, anon-WO0118547.455 |
| Gene |
UniProtKB-ID:
SKY_DROME,
Q0E8N9_DROME,
Q9VIH6_DROME,
M9PDI9_DROME,
M9PDV9_DROME
UniprotKB:
Q9VIH7,
Q0E8N9,
Q9VIH6,
M9PDI9,
M9PDV9
UniParc:
UPI0002946DFC,
UPI000294103B,
UPI00004C52EA,
UPI00001E1675,
UPI000007BEBE,
UPI0000078F7B,
UPI000007EBA6
EMBL:
AY118490,
BT120183,
AE014134,
AY118379,
AY069398
EnsemblGenome:
FBgn0032901
KO:
dme:Dmel_CG9339
|
| Nucleutide sequences |
EMBL-CDS:
AGB93184.1,
AAF53945.2,
ADB91431.1,
AAM48408.1,
AAS64731.1,
AAL39543.1,
AAM49859.1,
AAF53942.2,
AAN11097.2,
ACZ94312.1,
AAN11095.2,
AAS64730.1,
AAN11096.2,
AAF53943.2,
AGB93186.1,
AGB93185.1
Gene_ORFName:
CG9339,
Dmel_CG9339,
CG9339,
CG9339,
Dmel_CG9339,
CG9339,
Dmel_CG9339,
CG9339,
Dmel_CG9339
EnsemblGenome_TRS:
FBtr0330255,
FBtr0081442,
FBtr0081445,
FBtr0301961,
FBtr0081447,
FBtr0081441,
FBtr0081440,
FBtr0081443,
FBtr0081446,
FBtr0081444,
FBtr0330257,
FBtr0330256
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0291173,
FBpp0080974,
FBpp0080970,
FBpp0080976,
FBpp0303287,
FBpp0080971,
FBpp0080975,
FBpp0080969,
FBpp0080972,
FBpp0080973,
FBpp0303289,
FBpp0303288
RefSeq:
NP_724301.2,
NP_724303.2,
NP_724304.1,
NP_610073.1,
NP_724302.1,
NP_995739.1,
NP_001163026.1,
NP_001260651.1,
NP_724300.2,
NP_001260650.1,
NP_995738.1,
NP_001260649.1
|
| Others |
UniRef100:
UniRef100_M9PDI9,
UniRef100_Q0E8N9,
UniRef100_Q9VIH6,
UniRef100_M9PDV9,
UniRef100_Q9VIH7
UniRef90:
UniRef90_Q9VIH7
UniRef50:
UniRef50_Q9VIH7
UniGene:
Dm.2151
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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