| Type | Description |
|---|---|
| Definition | RHAU helicase |
| Date | Results | Publications |
|---|---|---|
| 2019-09-14 12:33:00 | This indicates that in an unexpectedly small set of genes, in which G-quadruplex motifs are unusually common in the 5'-UTR of their mRNAs, Rhau helicase is responsible for the regulation of their expression. | 30528389 |
| 2019-01-26 11:37:00 | The crystal structures of DHX36 in complex with RNA and DNA, revealing that G-rich tracts are specifically recognized by the helicase. The negatively charged G-quadruplex is recognized and destabilized by a positively charged binding cage and then unfolded via ATP-dependent ssDNA translocation activity. On the basis of these results, a conceptual G4 DNA-resolving mechanism is proposed. | 29429875 |
| 2017-06-10 11:08:00 | The study provides the first evidence that the unfolding kinetics of a G-quadruplex can be modulated by different nucleotide-bound states of the RHAU helicase (CG9323). | 28069994 |
| 2010-05-28 15:56:00 | CG9323 is the true ortholog of the human RHAU/DHX36 DEAH-box RNA helicase. CG9323 possesses guanine quadruplex-RNA binding and resolving activities. | 20472641 |
| Type | IDs |
|---|---|
| Synonymous | 38E.15, CG9323, DmRHAU, Dmel\CG9323, cg9323 |
| Gene |
UniProtKB-ID:
Q8SWT2_DROME
UniprotKB:
Q8SWT2
UniParc:
UPI0000076BB6
EMBL:
AE014134,
AY095176
EnsemblGenome:
FBgn0032883
KO:
dme:Dmel_CG9323
|
| Nucleutide sequences |
EMBL-CDS:
AAF53921.2,
AAM12269.1,
AGB93174.1
Gene_ORFName:
Dmel_CG9323,
CG9323
EnsemblGenome_TRS:
FBtr0081459,
FBtr0335147
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0307146,
FBpp0080988
RefSeq:
NP_001260639.1,
NP_610056.1
|
| Others |
UniRef100:
UniRef100_Q8SWT2
UniRef90:
UniRef90_Q8SWT2
UniRef50:
UniRef50_Q8SWT2
UniGene:
Dm.11353
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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