| Type | Description |
|---|---|
| Definition | toll like receptor adaptor molecule 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 12:19:00 | SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. | 29440514 |
| 2017-12-30 10:48:00 | Data suggest that endosomal localization of TICAM2 is essential for TLR4-mediated type I interferon-inducing signaling from endosomes; TICAM2 acts as scaffold protein and activates TICAM1; N-terminal myristoylation allows TICAM2 to anchor to endosomal membrane. (TICAM2 = toll like receptor adaptor molecule-2; TICAM1 = toll like receptor adaptor molecule-1; TLR4 = toll-like receptor 4) [REVIEW] | 28630139 |
| 2016-04-02 10:04:00 | Data show that Toll/IL-1R domain-containing adaptor molecule (TICAM)-2 possesses two conserved acidic amino acids, D91 and E92, which regulate TICAM-2 self-activation and signaling. | 26408662 |
| 2016-01-16 12:03:00 | Findings were SNPs in TICAM2 (P = 3.6 x 10(-6)) and IL1B (P = 4.3 x 10(-5)) associated with TB. | 25521228 |
| 2015-10-31 11:24:00 | TRAM plays a role in TLR7 signaling through a novel signaling axis towards the activation of anti-viral immunity. | 25211222 |
| Type | IDs |
|---|---|
| Synonymous | MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM |
| Gene |
UniProtKB-ID:
TCAM2_HUMAN
UniprotKB:
Q86XR7
UniParc:
UPI00003779F1,
UPI000015F970
EMBL:
AY304583,
AY304584,
AC010226,
AY232653,
CH471086,
AB091054,
AY304581,
BC109266,
AB097022,
AY275836,
AB109098,
BC109265,
AB446491,
AY304582
Ensembl:
ENSG00000243414
KO:
hsa:100302736,
hsa:353376
|
| Nucleutide sequences |
EMBL-CDS:
BAC77375.1,
BAC98397.1,
AAQ97430.1,
AAI09266.1,
BAC98399.1,
EAW48961.1,
AAQ97433.1,
AAP81748.1,
AAO74498.1,
AAI09267.1,
BAG55268.1,
EAW48960.1,
AAQ97431.1,
AAQ97432.1
Ensembl_TRS:
ENST00000427199
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000415139
RefSeq:
NP_067681.1
|
| Others |
UniRef100:
UniRef100_Q86XR7
UniRef90:
UniRef90_Q86XR7
UniRef50:
UniRef50_Q86XR7
UniGene:
Hs.718838
CCDS:
CCDS4119.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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