| Type | Description |
|---|---|
| Definition | glycyl-tRNA synthetase |
| Date | Results | Publications |
|---|---|---|
| 2019-03-02 10:11:00 | ignificant alterations of the vesicle-associated membrane protein-associated protein B (VAPB) and its downstream pathways such as mitochondrial calcium uptake and autophagy were detected in dominant GARS mutations. The role of VAPB has been supported by similar results in the GarsC210R mice. Our data suggest that altered mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) may be important disease mechanisms | 29648643 |
| 2018-05-19 11:11:00 | Gars mutations are associated with Charcot-Marie-Tooth disease type 2D. | 28351971 |
| 2018-04-14 10:33:00 | Results link the aberrant GlyRS-HDAC6 interaction to Charcot-Marie-Tooth disease type 2D pathology and suggest HDAC6 as an effective therapeutic target. | 29520015 |
| 2016-04-30 11:45:00 | findings link the selective pathology of Charcot-Marie-Tooth disease type 2D to the neomorphic binding activity of GlyRS(CMT2D) that antagonizes the VEGF-Nrp1 interaction, meaning the VEGF-Nrp1 signalling axis is an actionable target for treating CMT2D | 26503042 |
| 2015-10-31 10:23:00 | These results suggest that this animal model of CMT using an adenovirus may provide information regarding CMT as well as a useful strategy for the treatment of neuropathic pain. | 25120326 |
| Type | IDs |
|---|---|
| Synonymous | GENA202, Gena201, Nmf249, Sgrp23 |
| Gene |
UniProtKB-ID:
GARS_MOUSE
UniprotKB:
Q9CZD3
UniParc:
UPI00000276C3
EMBL:
AK165857,
BC021747,
AK146238
Ensembl:
ENSMUSG00000029777
KO:
mmu:353172
|
| Nucleutide sequences |
EMBL-CDS:
BAE27003.1,
AAH21747.1,
BAE38417.1
Ensembl_TRS:
ENSMUST00000003572
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000003572
RefSeq:
NP_851009.2
|
| Others |
UniRef100:
UniRef100_Q9CZD3
UniRef90:
UniRef90_Q9CZD3
UniRef50:
UniRef50_P41250
UniGene:
Mm.250004
CCDS:
CCDS39492.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员