| Type | Description |
|---|---|
| Definition | Topoisomerase 3alpha |
| Date | Results | Publications |
|---|---|---|
| 2016-10-22 11:27:00 | The results reported here demonstrate that mitochondrial Top3alpha ablation results in mitochondrial genome instability and its dysfunction, thereby accelerating the aging process. | 27067525 |
| 2012-08-25 10:20:00 | the Top3alpha C terminus has an important role in dHJ dissolution (by providing an interaction interface for Blm and DNA) and an essential function in vivo. | 22511792 |
| 2010-05-10 12:12:00 | described the phenotypes associated with mitochondrial dysfunction, including the female sterility and the loss of germ-line stem cells of males, as a result from topo IIIalpha deprivation. | 20308575 |
| 2010-01-21 00:00:00 | Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration | 16849422 |
| 2010-01-21 00:00:00 | partially relaxes a hypernegatively supercoiled plasmid substrate consistent with other purified topo IIIs. | 15537633 |
| Type | IDs |
|---|---|
| Synonymous | CG10123, DmTop3alpha, Dmel\CG10123, Top3a, Topo IIIalpha, dTopoIIIa, top3alpha, topo IIIalpha |
| Gene |
UniProtKB-ID:
TOP3A_DROME
UniprotKB:
Q9NG98
UniParc:
UPI00000074DE
EMBL:
AF255733,
AE014134,
BT015282
EnsemblGenome:
FBgn0040268
KO:
dme:Dmel_CG10123
|
| Nucleutide sequences |
EMBL-CDS:
AAF71288.1,
AAT94511.1,
AAF53813.2
Gene_ORFName:
CG10123
EnsemblGenome_TRS:
FBtr0081246
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0080787
RefSeq:
NP_523602.2
|
| Others |
UniRef100:
UniRef100_Q9NG98
UniRef90:
UniRef90_Q9NG98
UniRef50:
UniRef50_Q9NG98
UniGene:
Dm.2659
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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