| Type | Description |
|---|---|
| Definition | male-specific lethal 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-03-10 11:02:00 | In Drosophila melanogaster, transcriptional output from the single male X-chromosome is equalized to that of XX females by recruitment of the male-specific lethal (MSL) complex, which increases transcript levels of active genes 2-fold. | 27995349 |
| 2017-05-20 12:46:00 | Genetic and biochemical analyses reveal a functional interaction of MSL1 with CDK7, a subunit of the Cdk-activating kinase (CAK) complex of the general transcription factor TFIIH. Importantly, MSL1 depletion leads to decreased phosphorylation of Ser5 of RNA polymerase II. | 27183194 |
| 2013-05-18 11:05:00 | We show that SPT5 interacts directly with MSL1 in vitro and is required downstream of MSL complex recruitment, providing the first mechanistic data corroborating the elongation model of dosage compensation. | 23209435 |
| 2013-02-23 10:04:00 | The Msl1-mediated dimerization of the entire MSL complex is required for Msl2 binding, X chromosome recognition, and spreading along the X chromosome. | 23084835 |
| 2010-04-19 11:22:00 | Data suggest that the Y chromosome is likely to act through modulation of a process that is defective in roX1 roX2 mutants: X chromosome recognition or chromatin modification by the MSL complex. | 19704014 |
| Type | IDs |
|---|---|
| Synonymous | CG10385, Dmel\CG10385, MSL, MSL-1, MSL1, Msl 1-3, Msl-1, Msl1, i94, km(2)B, kmB, mls-1, msl, msl1 |
| Gene |
UniProtKB-ID:
MSL1_DROME,
X2J6S0_DROME
UniprotKB:
P50535,
X2J6S0
UniParc:
UPI0000076552
EMBL:
BT023828,
AE014134,
L42514
EnsemblGenome:
FBgn0005617
KO:
dme:Dmel_CG10385
|
| Nucleutide sequences |
EMBL-CDS:
AAZ86749.1,
AAF53689.1,
AAA98918.1,
AHN54568.1
Gene_ORFName:
CG10385,
CG10385,
Dmel_CG10385
EnsemblGenome_TRS:
FBtr0081130,
FBtr0343118,
FBtr0343118,
FBtr0081130
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0080674,
FBpp0309817,
FBpp0309817,
FBpp0080674
RefSeq:
NP_476896.1,
NP_001286054.1
|
| Others |
UniRef100:
UniRef100_P50535
UniRef90:
UniRef90_P50535
UniRef50:
UniRef50_P50535
UniGene:
Dm.458
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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