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35045 Dif

35045

Dif

Dorsal-related immunity factor

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition Dorsal-related immunity factor

研究结论

Date Results Publications
2019-08-17 11:49:00 Study shows that Drosophila miR-317 only targets Dif-Rc, but not Dif-Ra/b/d, implying that miRNAs can regulate different isoforms of an alternative splicing gene to fine tune immune responses and maintain homeostasis in post-transcriptional level. During Gram-positive bacterial infection, the overexpressed miR-317 flies have poor survival outcome suggesting that the miR-317 might play a key role in Drosophila survival. 30708026
2017-06-10 12:26:00 These results, not only revealed a novel function and modulation pattern of miR-958, but also provided a new insight into the underlying molecular mechanisms of Toll signaling in regulation of innate immunity. 27974298
2016-04-16 10:22:00 Fasting increases survival to cold in dif mutant Drosophila melanogaster. 25663303
2013-01-26 11:17:00 DIF factor seems to be involved in the response to fungal infection after a mild cold stress and in the resistance to heat. DIF seems to have no role in the increased longevity of non-infected flies and resistance to a severe cold shock. 22791143
2010-10-04 12:33:00 Data show that the DIF and Relish complex is detectable in whole animal extracts, suggesting that this heterodimer may function in vivo to increase the spectrum and level of antimicrobial peptide production in response to different infections. 20679214

名称对应

Type IDs
Synonymous 6794, CG6794, DIF, Dmel\CG6794, dif
Gene
UniProtKB-ID: DIF_DROME, E1JHK2_DROME, E1JHK1_DROME
UniprotKB: P98149, E1JHK2, E1JHK1
UniParc: UPI00001248E8, UPI0001C00053
EMBL: AE014134, L29015, AY118375, BT025231
EnsemblGenome: FBgn0011274
KO: dme:Dmel_CG6794
Nucleutide sequences
EMBL-CDS: AAM48404.1, AAA28465.1, ABF17922.1, AAN10989.1, AAF53608.1, ACZ94284.1, ACZ94285.1
Gene_ORFName: CG6794, CG6794, Dmel_CG6794, Dmel_CG6794, CG6794
EnsemblGenome_TRS: FBtr0081009, FBtr0081008, FBtr0301578, FBtr0301577, FBtr0081008, FBtr0301578, FBtr0081009
Protein sequencees
EnsemblGenome_PRO: FBpp0080561, FBpp0290793, FBpp0080562, FBpp0290792, FBpp0290793, FBpp0080562, FBpp0080561
RefSeq: NP_523589.2, NP_001162999.1, NP_001162998.1, NP_724050.1
Others
UniRef100: UniRef100_E1JHK2, UniRef100_P98149
UniRef90: UniRef90_P98149, UniRef90_E1JHK2
UniRef50: UniRef50_E1JHK2, UniRef50_P98149
UniGene: Dm.19845

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