| Type | Description |
|---|---|
| Definition | hyperpolarization activated cyclic nucleotide gated potassium channel 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 12:53:00 | Mutating two residues of HCN1 located at the interface between the voltage sensor and the pore domain resulted in the open state upon depolarization instead of hyperpolarization. | 32184399 |
| 2020-05-09 12:11:00 | All-atom molecular dynamics simulations (~20 mus) of HCN1 channel under hyperpolarization reveals an initial downward movement of the S4 voltage-sensor but following the transfer of last gating charge, the S4 breaks into two sub-helices with the lower sub-helix becoming parallel to the membrane. | 31774399 |
| 2019-08-24 12:19:00 | Study found stronger h-channel (HCN1)-related membrane properties in supragranular pyramidal neurons in human temporal cortex, compared to mouse supragranular pyramidal neurons in temporal association area. H-channels contribute to between-species differences in a fundamental neuronal property. | 30392798 |
| 2019-07-20 12:57:00 | The results expand the clinical spectrum related to HCN1 variants to include common generalized epilepsy phenotypes and further illustrate how HCN1 has a pivotal function in brain development and control of neuronal excitability. | 30351409 |
| 2019-05-25 11:42:00 | No significant association was found between HCN1/HCN2 alleles, genotypes or haplotypes, and drug resistance in patients, however, it was suggested that HCN2 rs3752158 is involved in the susceptibility to juvenile myoclonic epilepsy. | 29047147 |
| Type | IDs |
|---|---|
| Synonymous | BCNG-1, BCNG1, EIEE24, HAC-2 |
| Gene |
UniProtKB-ID:
HCN1_HUMAN,
Q86WJ6_HUMAN
UniprotKB:
O60741,
Q86WJ6
UniParc:
UPI000000D7BE,
UPI00001AED69
EMBL:
AC117529,
AF064876,
AF488549,
AC114975,
AC138520,
AC099514
Ensembl:
ENSG00000164588
KO:
hsa:348980
|
| Nucleutide sequences |
EMBL-CDS:
AAC39759.1,
AAO49469.1
Ensembl_TRS:
ENST00000303230
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000307342
RefSeq:
NP_066550.2
|
| Others |
UniRef100:
UniRef100_O60741,
UniRef100_Q86WJ6
UniRef90:
UniRef90_O60741
UniRef50:
UniRef50_O60741
UniGene:
Hs.353176
CCDS:
CCDS3952.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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