| Type | Description |
|---|---|
| Definition | GEN1 Holliday junction 5' flap endonuclease |
| Date | Results | Publications |
|---|---|---|
| 2019-08-31 11:36:00 | The tight binding of GEN1 monomer to intact- and singly-cleaved Holliday junctions empowers it as the last resort to process Holliday junctions that escape the primary mechanisms | 30590761 |
| 2018-11-10 11:56:00 | Using or FA-P cells complemented with SLX4 mutants that abrogate interaction with MUS81 or SLX1, we show that SLX4 cooperates with MUS81 to introduce DSBs after replication stress but also counteracts pathological targeting of demised forks by GEN1. | 28290553 |
| 2018-04-21 11:29:00 | GEN1 efficiently cleaves both single and double Holliday junctions contained within large recombination intermediates. Moreover, we find that GEN1 exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA. | 28049850 |
| 2017-09-23 12:28:00 | the in vitro activities of DmGen and HsGEN1 are strikingly similar. | 28369583 |
| 2017-08-12 10:31:00 | Data suggest that dimeric GEN1 binds with high affinity/selectivity to Holliday junctions, introducing two symmetrical hydrolytic cleavages of phosphodiester backbone; at present, less is known about SLX1-SLX4-MUS81-EME1 resolving enzyme complex. (GEN1 = Holliday junction 5' flap endonuclease; SLX = structure-specific endonuclease subunit; MUS81 = MUS81 endonuclease; EME1 = essential meiotic endonuclease 1) [REVIEW] | 27990631 |
| Type | IDs |
|---|---|
| Synonymous | Gen |
| Gene |
UniProtKB-ID:
GEN_HUMAN
UniprotKB:
Q17RS7
UniParc:
UPI00004113DA
EMBL:
AC093731,
BC117204,
BC117206,
AK131387
Ensembl:
ENSG00000178295
KO:
hsa:348654
|
| Nucleutide sequences |
EMBL-CDS:
BAD18538.1,
AAI17207.1,
AAI17205.1
Ensembl_TRS:
ENST00000381254,
ENST00000317402
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000318977,
ENSP00000370653
RefSeq:
XP_011531122.1,
XP_006712068.1,
NP_001123481.3,
NP_872431.5,
XP_011531124.1,
XP_011531123.1,
XP_005262670.1
|
| Others |
UniRef100:
UniRef100_Q17RS7
UniRef90:
UniRef90_Q17RS7
UniRef50:
UniRef50_Q17RS7
UniGene:
Hs.467793
CCDS:
CCDS1691.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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