| Type | Description |
|---|---|
| Definition | Son of sevenless |
| Date | Results | Publications |
|---|---|---|
| 2016-06-04 10:04:00 | data support a model in which Robo's ligand-dependent internalization from cell surface to late endosome is essential for receptor activation and proper repulsive guidance at the midline by allowing recruitment of the downstream effector Son of Sevenless | 26335920 |
| 2014-11-29 10:53:00 | identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris | 25099352 |
| 2010-01-21 00:00:00 | SosM98, an allele with a single amino acid substitution in the RacGEF motif, functions as a dominant negative in vivo to downregulate receptor tyrosine kinase signaling. | 15286999 |
| 2010-01-21 00:00:00 | These results provide in vivo evidence that the Ras and RhoGEF domains of Sos are separable signaling modules and support a model in which Robo recruits Sos to the membrane via Dock to activate Rac during midline repulsion. | 17114045 |
| 2010-01-21 00:00:00 | Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1). | 12673197 |
| Type | IDs |
|---|---|
| Synonymous | 2.3, 34Ea, BG:DS00941.4, CG7793, Dmel\CG7793, E(sev)2A, E(var)189, EC2-5, EK2-8, EY2-3, SOS, Sos1, Su(tor)2-2, br24, br25, dSos, dme-SOS, l(2)34Ea, l(2)Sos, l(2)br24, l(2)br25, l(2)k05224, l(2)k06321, sos |
| Gene |
UniProtKB-ID:
SOS_DROME
UniprotKB:
P26675
UniParc:
UPI000007881B
EMBL:
AF459585,
AF459574,
BT015294,
AY058749,
AF459579,
AF459573,
AF459580,
AE014134,
M83931,
AF459575,
AF459584,
AF459582,
AF459571,
AF459569,
AF459578,
AF459583,
AF459568,
AF459570,
AF459572,
AF459566,
AF459576,
AF459577,
M77501,
AF459581,
AF459567
EnsemblGenome:
FBgn0001965
KO:
dme:Dmel_CG7793
|
| Nucleutide sequences |
EMBL-CDS:
AAN61399.1,
AAB04680.1,
AAN61384.1,
AAN61386.1,
AAN61383.1,
AAF53336.2,
AAA28904.1,
AAN61395.1,
AAL13978.1,
AAN61392.1,
AAN61385.1,
AAN61382.1,
AAN61393.1,
AAN61390.1,
AAN61388.1,
AAN61398.1,
AAN61391.1,
AAN61394.1,
AAN61396.1,
AAN61389.1,
AAN61401.1,
AAN61400.1,
AAT94523.1,
AAN61387.1,
AAN61397.1
Gene_ORFName:
CG7793
EnsemblGenome_TRS:
FBtr0080541
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0080118
RefSeq:
NP_476597.2
|
| Others |
UniRef100:
UniRef100_P26675
UniRef90:
UniRef90_P26675
UniRef50:
UniRef50_P26675
UniGene:
Dm.4109
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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