| Type | Description |
|---|---|
| Definition | insulin degrading enzyme |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 12:18:00 | Of the 15 variants, 3 variants (rs13405728 in LHCGR; rs13429458 in THADA and rs2209972 IDE genes) were found to be associated with PCOS. The association was successfully replicated in an independent cohort. Insilico analysis categorized two variants (rs13429458-THADA and rs2209972-IDE genes) as deleterious. | 32416252 |
| 2019-07-20 10:14:00 | TUDCA also increased IDE expression in human hepatic cell line HepG2. | 29093479 |
| 2019-06-08 11:05:00 | IDE displays a large opening between the homologous ~55 kDa N- and C-terminal halves to allow selective substrate capture based on size and charge complementarity. Insulin-bound IDE structures explain how IDE processively degrades insulin by stochastically cutting either chain without breaking disulfide bonds. | 29596046 |
| 2018-04-14 11:53:00 | These results support the hypothesis that IDE gene expression in different areas of Alzheimer's patient's brains. | 28164769 |
| 2017-07-22 13:22:00 | People with allelic variation in four genes related to cardiovascular diseases and metabolism were more likely to die: apolipoprotein (APO)C1 GG and AG carriers, APOE varepsilon4 carriers, insulin-degrading enzyme (IDE) TC carriers, and phosphatidylinositol 3-kinase (PI3KCB) GG carriers. | 27806189 |
| Type | IDs |
|---|---|
| Synonymous | INSULYSIN |
| Gene |
UniProtKB-ID:
IDE_HUMAN,
A0A3B3ISG5_HUMAN,
B3KSB8_HUMAN
UniprotKB:
P14735,
A0A3B3ISG5,
B3KSB8
UniParc:
UPI000013D6B6,
UPI000191546C,
UPI000387CEBD,
UPI00003E29DD
EMBL:
BC096336,
AL356128,
AK316407,
M21188,
CH471066,
BC096339,
BC096337,
AK093287,
AK312810
Ensembl:
ENSG00000119912
KO:
hsa:3416
|
| Nucleutide sequences |
EMBL-CDS:
AAA52712.1,
AAH96337.1,
EAW50090.1,
EAW50091.1,
BAG35668.1,
AAH96336.1,
AAH96339.1,
BAH14778.1,
BAG52680.1
Ensembl_TRS:
ENST00000371581,
ENST00000265986,
ENST00000650060
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000265986,
ENSP00000360637,
ENSP00000497272
RefSeq:
XP_016871679.1,
NP_001309722.1,
NP_001309724.1,
NP_004960.2,
XP_016871678.1,
NP_001309723.1,
NP_001309726.1,
XP_016871676.1,
NP_001159418.1,
XP_016871677.1,
NP_001309725.1
|
| Others |
UniRef100:
UniRef100_A0A337RWQ6,
UniRef100_P14735,
UniRef100_A0A3B3ISG5
UniRef90:
UniRef90_P14735
UniRef50:
UniRef50_P14735
UniGene:
Hs.500546
CCDS:
CCDS7421.1,
CCDS53554.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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