| Type | Description |
|---|---|
| Definition | hydroxycarboxylic acid receptor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-22 15:29:00 | Niacin Ameliorates Hepatic Steatosis by Inhibiting Lipogenesis Via a GPR109A-Mediated Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet. | 31858105 |
| 2020-08-13 18:51:00 | Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway. | 32039055 |
| 2020-07-25 11:48:00 | This review summarizes the use of niacin in treatment of dyslipidemia, the pharmacogenetics of niacin response and the potential role of HCAR2 signaling in the treatment of a variety of inflammatory and metabolic diseases. | 31617441 |
| 2020-06-20 10:53:00 | C. butyricum decreased the fecal secondary BA contents, increased the cecal SCFA quantities, and activated G-protein coupled receptors (GPRs), such as GPR43 and GPR109A. The analysis of clinical specimens revealed that the expression of GPR43 and GPR109A gradually decreased from human normal colonic tissue to adenoma to carcinoma | 31734354 |
| 2020-04-04 12:32:00 | These results indicate that during aging, GPR109A modulates de novo lipid accumulation in liver and adipose tissue, and its dysregulation can lead to age-associated obesity and hepatic steatosis. | 30659164 |
| Type | IDs |
|---|---|
| Synonymous | GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g |
| Gene |
UniProtKB-ID:
HCAR2_HUMAN,
A0A4Y1JWQ0_HUMAN
UniprotKB:
Q8TDS4,
A0A4Y1JWQ0
UniParc:
UPI000003BCD5
EMBL:
BC027965,
EU012026,
BC056419,
AB065876,
AB083632,
AY148884,
KU285440
Ensembl:
ENSG00000182782
KO:
hsa:338442
|
| Nucleutide sequences |
EMBL-CDS:
AAH27965.1,
AAH56419.1,
AAN71621.1,
BAB89345.1,
ABS29270.1,
BAC06094.1,
APT70322.1
Ensembl_TRS:
ENST00000328880
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000375066
RefSeq:
NP_808219.1
|
| Others |
UniRef100:
UniRef100_Q8TDS4
UniRef90:
UniRef90_Q8TDS4
UniRef50:
UniRef50_Q9EP66
UniGene:
Hs.524812
CCDS:
CCDS9235.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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