| Type | Description |
|---|---|
| Definition | sodium leak channel, non-selective |
| Date | Results | Publications |
|---|---|---|
| 2020-08-29 12:49:00 | Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. | 32620897 |
| 2020-06-13 11:55:00 | PRMT7-mediated NALCN inhibition provides a potential target for the development of therapeutic tools for neurological diseases | 31601786 |
| 2019-04-13 10:58:00 | NALCN has been identified as a core effector of inhibitory G protein-coupled receptors. | 30556810 |
| 2017-11-11 13:53:00 | The authors discovered that substantia nigra pars reticulata neurons express the sodium leak channel, NALCN, and that neurons lacking NALCN have impaired spontaneous firing. In addition, NALCN is involved in the modulation of excitability by changes in glycolysis and by activation of muscarinic acetylcholine receptors. | 27177420 |
| 2017-07-15 12:11:00 | We show here that Nalcn, a unique channel that generates "leak" sodium currents, regulates excitability and neuromodulation of RTN neurons and CO2-stimulated breathing. Thus, this work defines a specific function for this enigmatic channel in an important physiological context. | 27488637 |
| Type | IDs |
|---|---|
| Synonymous | A530023G15Rik, AI849508, Vgcnl1 |
| Gene |
UniProtKB-ID:
NALCN_MOUSE,
E9QLE4_MOUSE
UniprotKB:
Q8BXR5,
E9QLE4
UniParc:
UPI00016277D8,
UPI00000EA51A,
UPI0000D63194
EMBL:
AK044431,
AC102783,
CT010566,
AC154677,
AK039034,
AC124818
Ensembl:
ENSMUSG00000000197
KO:
mmu:338370
|
| Nucleutide sequences |
EMBL-CDS:
BAC30213.1,
BAC31915.1
Ensembl_TRS:
ENSMUST00000000201
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000000201
RefSeq:
XP_036014575.1,
XP_036014578.1,
XP_036014577.1,
XP_011243396.1,
XP_030103726.1,
XP_036014576.1,
XP_017171555.1,
XP_036014579.1,
NP_796367.3,
XP_036014574.1
|
| Others |
UniRef100:
UniRef100_E9QLE4,
UniRef100_Q8BXR5
UniRef90:
UniRef90_Q8BXR5
UniRef50:
UniRef50_Q8BXR5
UniGene:
Mm.255348
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员