| Type | Description |
|---|---|
| Definition | little imaginal discs |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 11:34:00 | KDM5 functions by promoting the endoreplication of prothoracic gland cells, a process that increases ploidy and is rate limiting for the expression of ecdysone biosynthetic genes. KDM5 activates the expression of the receptor tyrosine kinase torso, which then promotes polyploidization and growth through activation of the MAPK signaling pathway. | 31862793 |
| 2019-11-23 11:04:00 | Reducing KDM5 causes intestinal barrier dysfunction and changes in social behavior that correlates with compositional changes in the gut microbiota. | 30902578 |
| 2019-06-22 12:06:00 | the primary defect of the KDM5(A512P) mutation is a loss of histone demethylase activity and reveal an unexpected role for this enzymatic function in gene activation. | 29490272 |
| 2018-12-22 12:30:00 | However, for the N terminal region harboring both a PHD and an ARID finger, Lid anchors to the NuMat via both protein-protein and protein-DNA interactions. The association of JmjC domain with NuMat is the first report of the association of a demethylase domain with NuMat suggesting that Lid, a demethylase, being part of NuMat might be involved in regulating the chromatin dynamics via its NuMat association. | 30207309 |
| 2018-10-13 11:49:00 | Analyses reveal KDM5 as a key regulator of larval growth and offer an invaluable tool for defining the biological activities of KDM5 family proteins. | 29764901 |
| Type | IDs |
|---|---|
| Synonymous | CG9088, Dmel\CG9088, KDM5, Kdm5, LID, Lid, dJARID1, dKDM5, dKDM5/LID, kdm5, l(2)10424 |
| Gene |
UniProtKB-ID:
KDM5_DROME,
M9NEV0_DROME
UniprotKB:
Q9VMJ7,
M9NEV0
UniParc:
UPI000007F911
EMBL:
AY095051,
AE014134
EnsemblGenome:
FBgn0031759
KO:
dme:Dmel_CG9088
|
| Nucleutide sequences |
EMBL-CDS:
AAM11379.1,
AAF52319.1,
AAN10569.1,
AHN54164.1,
AFH03582.1,
AFH03583.1,
AFH03584.1
Gene_ORFName:
CG9088,
Dmel_CG9088,
CG9088
EnsemblGenome_TRS:
FBtr0307070,
FBtr0307069,
FBtr0307071,
FBtr0345336,
FBtr0079232,
FBtr0079231,
FBtr0079231,
FBtr0307071,
FBtr0307070,
FBtr0345336,
FBtr0307069,
FBtr0079232
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0078862,
FBpp0297912,
FBpp0311492,
FBpp0078863,
FBpp0297913,
FBpp0297914,
FBpp0311492,
FBpp0078862,
FBpp0297914,
FBpp0297912,
FBpp0078863,
FBpp0297913
RefSeq:
NP_001245909.1,
NP_001285649.1,
NP_523486.1,
NP_001245910.1,
NP_001245908.1,
NP_723140.1
|
| Others |
UniRef100:
UniRef100_Q9VMJ7
UniRef90:
UniRef90_Q9VMJ7
UniRef50:
UniRef50_Q9VMJ7
UniGene:
Dm.2779
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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