wrb - tryptophan rich basic protein-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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335756 wrb

基因描述

Type	Description
Definition	tryptophan rich basic protein

研究结论

Date	Results	Publications
2017-06-24 10:40:00	Wrb may have tissue-specific functions in the visual system and heart, or can maintain dual functions even in the same tissue. The selectivity of the defects at sensory neuron ribbon synapses suggests unique biosynthetic demands for cells bearing ribbon synapses, but may also point to a novel role for Wrb acting through the GET pathway in synaptic function.	27273592
2016-11-05 11:43:00	WRB plays a critical role in synaptic functions in inner-ear hair cells and retinal photoreceptors.	26593130

名称对应

Type	IDs
Synonymous	pwi, wu:ft06h05, zgc:101856
Gene	UniProtKB-ID: GET1_DANRE UniprotKB: Q6DRM0 UniParc: UPI00003BEE54 EMBL: AY648739, BC150353 Ensembl: ENSDARG00000074271 KO: dre:335756
Nucleutide sequences	EMBL-CDS: AAT68057.1, AAI50354.1 Ensembl_TRS: ENSDART00000114134
Protein sequencees	Ensembl_PRO: ENSDARP00000100769 RefSeq: NP_001003413.1
Others	UniRef100: UniRef100_Q6DRM0 UniRef90: UniRef90_Q6DRM0 UniRef50: UniRef50_Q6DRM0 UniGene: Dr.86086

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
28252024	Evolution of complexity in the zebrafish synapse proteome. Nat Commun Ãlex BayÃ©s , Mark O Collins , Rita Reig-Viader , Gemma Gou , David Goulding , Abril Izquierdo , Jyoti S Choudhary , Richard D Emes , Seth G N Grant	2017-03-02	-
27458190	Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. EMBO J Christian Vogl , Iliana Panou , Gulnara Yamanbaeva , Carolin Wichmann , Sara J Mangosing , Fabio Vilardi , Artur A Indzhykulian , Tina PangrÅ¡iÄ , Rosamaria Santarelli , Montserrat Rodriguez-Ballesteros , Thomas Weber , Sangyong Jung , Elena Cardenas , Xudong Wu , Sonja M Wojcik , Kelvin Y Kwan , Ignacio Del Castillo , Blanche Schwappach , Nicola Strenzke , David P Corey , Shuh-Yow Lin , Tobias Moser	2016-12-01	-
27273592	Mutation of wrb, a Component of the Guided Entry of Tail-Anchored Protein Pathway, Disrupts Photoreceptor Synapse Structure and Function. Invest. Ophthalmol. Vis. Sci. Lauren L Daniele , Farida Emran , Glenn P Lobo , Robert J Gaivin , Brian D Perkins	2016-06-01	-
26593130	The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors. J. Physiol. (Lond.) Shuh-Yow Lin , Melissa A Vollrath , Sara Mangosing , Jun Shen , Elena Cardenas , David P Corey	2016-02-15	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
19652097	Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Circulation David J Milan , Albert M Kim , Jeffrey R Winterfield , Ian L Jones , Arne Pfeufer , Serena Sanna , Dan E Arking , Adam H Amsterdam , Khaled M Sabeh , John D Mably , David S Rosenbaum , Randall T Peterson , Aravinda Chakravarti , Stefan KÃ¤Ã¤b , Dan M Roden , Calum A MacRae	2009-08-18	-
16109975	The zebrafish gene map defines ancestral vertebrate chromosomes. Genome Res. Ian G Woods , Catherine Wilson , Brian Friedlander , Patricia Chang , Daengnoy K Reyes , Rebecca Nix , Peter D Kelly , Felicia Chu , John H Postlethwait , William S Talbot	2005-09-01	fgfr4, pik3r3b, trpv6, poldip2, dnase2, rtf1, ube2g1b, ppp1r14bb, pvalb3, znf207b, olig1, sufu, msi2a, ppp4ca, ppp1cb, socs9, nhp2, kat8, laptm4a, fsta, mthfd2, mob1a, dyrk1aa, greb1l, fn1a, aldh9a1a.1, cpt2, sh3gl1a, vps18, arrdc1a, sv2bb, idh1, sb:cb37, tle3b, erbb4a, ap1g2, parp2, hbl3, dhx37, pcsk7, rmdn3, gtf3ab, kif3b, npl, sall1b, pard6ga, arfgef1, gdf5, cog1, casr, slc25a28, urb1, ndufv3, trip11, casq2, mpz, rps9, vars, spry4, ube2ia, dlg1, sim2, blzf1, copb2, sec22ba, tnfsf10l, ednraa, pklr, vcana, ywhag1, jag1a, jag2b, jag1b, vim, tfap2a, prps1a, atic, cyp1a, ckbb, psap, gbx1, ptk2ab, meis1b, mkrn2, rbp5, crabp2a, ccna2, hdac1, csnk1a1, mak16, actl6a, dtl, stil, pole2, slc25a5, cct7, cct3, smc4, kif11
15716491	Identification of zebrafish insertional mutants with defects in visual system development and function. Genetics Jeffrey M Gross , Brian D Perkins , Adam Amsterdam , Ana EgaÃ±a , Tristan Darland , Jonathan I Matsui , Salvatore Sciascia , Nancy Hopkins , John E Dowling	2005-05-01	odc1, prkci, ccna2, mcm3, atp6v1e1b, atp6v0ca, mcm2, atp6ap1b, mpp5a, smarca5, ints7, atp6v1h, cpsf4, paics, atp6v0d1, trappc11, nfyc, wrb, fen1, dmap1, polr3f, uhrf1, rfc4, ift57, ift172, atp6v1f, rbm42, rfc5, sf1, copz1, nrf1, med29, tyms
15256591	Identification of 315 genes essential for early zebrafish development. Proc. Natl. Acad. Sci. U.S.A. Adam Amsterdam , Robert M Nissen , Zhaoxia Sun , Eric C Swindell , Sarah Farrington , Nancy Hopkins	2004-08-31	-
12477932	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team	2002-12-24	-

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