| Type | Description |
|---|---|
| Definition | unpaired 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-12-01 11:53:00 | we show that loss of PGANT4 disrupts the mucosal barrier, resulting in epithelial expression of the IL-6-like cytokine Upd3, leading to activation of signaling, differentiation of cells that form the progenitor cell niche, and abnormal proliferation of progenitor cells. This niche disruption could be recapitulated by overexpressing upd3 and rescued by deleting upd3, highlighting a crucial role for this cytokine. | 29127201 |
| 2017-11-25 12:39:00 | Infection-induced upd3 expression in enterocytes requires the indirect functions of snail and its transcriptional co-repressors, as well as homeodomain transcription factors and epigenetic regulators. Upd3 transcription is regulated by a combination of microbe-responsive, cell-specific and region-specific enhancers. | 29108021 |
| 2017-05-13 14:25:00 | Our study shows that haemocytes express the three upd genes and that injury markedly induces the expression of upd3 by the JNK pathway in haemocytes, which in turn activates the pathway in the fat body and the gut. Surprisingly, release of Upd3 from haemocytes upon injury can remotely stimulate stem cell proliferation and the expression of Drosomycin-like genes in the intestine. | 27231872 |
| 2015-04-18 12:02:00 | controls glucose metabolism and reduces lifespan on a lipid-rich diet via activation of the pathway | 25601202 |
| 2015-01-31 11:36:00 | unpaired 3 is essential for a subset of JAK-mediated developmental functions. | 25245869 |
| Type | IDs |
|---|---|
| Synonymous | CG15062, CG15062/CG5963, CG33542, CG5963, Dmel\CG33542, UPD3, Upd, Upd-3, Upd-like, Upd3, cg15062, cg5963, od, odsy, os, sy, upd-3 |
| Gene |
UniProtKB-ID:
Q59E38_DROME
UniprotKB:
Q59E38
UniParc:
UPI00015D9B86
EMBL:
BT044177,
AE014298
EnsemblGenome:
FBgn0053542
KO:
dme:Dmel_CG33542
|
| Nucleutide sequences |
EMBL-CDS:
AAX52505.2,
ACH92242.1
Gene_ORFName:
Dmel_CG33542,
CG33542
EnsemblGenome_TRS:
FBtr0113465
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0112376
RefSeq:
NP_001097014.1
|
| Others |
UniRef100:
UniRef100_Q59E38
UniRef90:
UniRef90_Q59E38
UniRef50:
UniRef50_Q59E38
UniGene:
Dm.26662
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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