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33458 Hrs

33458

Hrs

Hepatocyte growth factor regulated tyrosine kinase substrate

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition Hepatocyte growth factor regulated tyrosine kinase substrate

研究结论

Date Results Publications
2017-08-05 10:59:00 These results reveal that ESCRT-0 (ESCRT-0 components stam and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells. 27056762
2016-06-11 10:59:00 The present report is devoted to the clarification and detailing of the Hrs effect on D/V, as well as on A/P borders of the imaginal wing disc compartments in Drosophila melanogaster. 27169237
2015-12-12 11:16:00 Hrs is dispensable for cytokinesis. Finally, it was found that although Drosophila Hrs does not localize at acrosome, the other endosomal markers--Rab4, Rab7, and Rab11--are detected at the organelle. 26591063
2015-06-20 12:30:00 Drosophila epithelia lacking Hrs and Stam, accumulate Notch and Dome in endosomes, maintain normal apico-basal polarity and proliferation control and do not show ectopic Notch signaling activation. 24718108
2014-08-23 11:17:00 Hrs mediates Smo trafficking in the late endosome by not only promoting Smo ubiquitination but also blocking Smo phosphorylation. 24244405

名称对应

Type IDs
Synonymous CG2903, DmHRS, Dmel\CG2903, HRS, HRS-2, Vps27, dHrs, hrs, l(2)23AB5, l(2)23Ad, l(2)23Ad(Hrs), vps27
Gene
UniProtKB-ID: HRS_DROME, C9QP23_DROME, B7FNJ7_DROME
UniprotKB: Q960X8, C9QP23, B7FNJ7
UniParc: UPI00000815E7, UPI00000073C9
EMBL: AY051789, AE014134, BT053687, BT001591, AY071846, BT099905
EnsemblGenome: FBgn0031450
KO: dme:Dmel_CG2903
Nucleutide sequences
EMBL-CDS: AAN71346.1, AAN10412.2, AAL60055.1, AAF51221.2, AAK93213.1, AAF51222.1, ACX32976.1, ACK77602.1
Gene_ORFName: CG2903
EnsemblGenome_TRS: FBtr0089751, FBtr0089750, FBtr0089749, FBtr0089749, FBtr0089750, FBtr0089751
Protein sequencees
EnsemblGenome_PRO: FBpp0088690, FBpp0088691, FBpp0088692, FBpp0088690, FBpp0088691, FBpp0088692
RefSeq: NP_722830.2, NP_722831.1, NP_525099.3
Others
UniRef100: UniRef100_C9QP23, UniRef100_Q960X8
UniRef90: UniRef90_Q960X8, UniRef90_C9QP23
UniRef50: UniRef50_C9QP23, UniRef50_Q960X8
UniGene: Dm.274

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