| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase non-receptor type 11a |
| Date | Results | Publications |
|---|---|---|
| 2019-03-09 12:34:00 | We...propose that Shp2 acts as a transient brake to the developmental myelination process. Furthermore, we show that Shp2 regulates oligodendrocyte differentiation following demyelination | 29217681 |
| 2017-11-25 15:21:00 | In MYCN transgenic fish, Gab2 overexpression activated the Shp2-Ras-Erk pathway, enhanced neuroblastoma induction, and increased tumor penetrance. | 28329685 |
| 2015-12-05 10:59:00 | Fer knockdown cooperated with NS and LS, but not wild type Shp2 to induce developmental defects, suggesting a role for Fer in the pathogenesis of both NS and LS. | 25184253 |
| 2015-01-17 12:37:00 | functions of ptpn11 genes in Zebrafish development | 24736444 |
| 2014-06-14 10:58:00 | Shp2 variant-mediated hyperactivation of MAPK signaling leads to impaired cilia function in Kupffer's vesicle, causing left-right asymmetry defects and defective early cardiac development. | 24718990 |
| Type | IDs |
|---|---|
| Synonymous | fa14b09, ptpn11, shp2, wu:fa14b09, wu:fi24f03, zgc:55388 |
| Gene |
UniProtKB-ID:
Q7ZW17_DANRE
UniprotKB:
Q7ZW17
UniParc:
UPI000000B7C7
EMBL:
BC164416,
BC045328
KO:
dre:333979
|
| Nucleutide sequences |
EMBL-CDS:
AAI64416.1,
AAH45328.1
|
| Protein sequencees |
RefSeq:
NP_956140.1
|
| Others |
UniRef100:
UniRef100_Q7ZW17
UniRef90:
UniRef90_F1QZU5
UniRef50:
UniRef50_P29350-4
UniGene:
Dr.75924,
Dr.104919
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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