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33392 aop

33392

aop

anterior open

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition anterior open

研究结论

Date Results Publications
2019-12-21 11:25:00 In Drosophila, reduced insulin/IGF signaling extends lifespan by coordinating activation of Aop and Foxo. Aop and Foxo bind the same genomic loci, and individually, they affect similar transcriptional programs in vivo. In combination, Aop can both moderate or synergise with Foxo, dependent on promoter context. Also, Foxo and Aop oppose the gene-regulatory activity of Pnt. 31356597
2019-03-02 12:25:00 a spectacular range of affinities lies latent within the SAM domain of Yan, and that these affinities must be tuned to preserve transcriptional repression and biological function during development. 30412049
2018-08-04 11:19:00 a new layer of regulation whereby Yan and Pointed co-occupy regulatory elements to repress gene expression in a coordinated manner, with Pointed being unexpectedly required for the genome-wide occupancy of both Yan and the co-repressor Groucho. 29848501
2018-06-30 11:35:00 Yan recruitment promoted by this high-affinity ETS supersite not only biases Yan-Pnt competition at the specific CRM but also organizes Yan-repressive complexes in three dimensions across the eve locus 29535190
2017-07-01 11:20:00 DNA Occupancy of Polymerizing 28076810

名称对应

Type IDs
Synonymous AOP, Aop, Aop/Yan, CG3166, DROYANET, DROYANETSB, Dmel\CG3166, SK2-1, YAN, Yan, aop/yan, fus6, pok, yan, yan/pok
Gene
UniProtKB-ID: POK_DROME, M9PC88_DROME
UniprotKB: Q01842, M9PC88
UniParc: UPI00001247A4
EMBL: BT015272, BT010237, M97693, D10228, AE014134
EnsemblGenome: FBgn0000097
KO: dme:Dmel_CG3166
Nucleutide sequences
EMBL-CDS: AAQ23555.1, AAF51297.1, BAA01080.1, AAA29023.1, AAN10445.1, AAT94501.1, AGB92445.1, AGB92447.1, AGB92446.1
Gene_ORFName: CG3166, Dmel_CG3166, CG3166
EnsemblGenome_TRS: FBtr0330660, FBtr0077851, FBtr0330659, FBtr0077850, FBtr0330658, FBtr0330659, FBtr0330660, FBtr0077851, FBtr0330658, FBtr0077850
Protein sequencees
EnsemblGenome_PRO: FBpp0303508, FBpp0303510, FBpp0077522, FBpp0303509, FBpp0077523, FBpp0303509, FBpp0303510, FBpp0303508, FBpp0077522, FBpp0077523
RefSeq: NP_001259909.1, NP_001259908.1, NP_722766.1, NP_523455.2, NP_001259910.1
Others
UniRef100: UniRef100_Q01842
UniRef90: UniRef90_Q01842
UniRef50: UniRef50_Q01842
UniGene: Dm.267

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