| Type | Description |
|---|---|
| Definition | kielin/chordin-like protein |
| Date | Results | Publications |
|---|---|---|
| 2017-06-10 11:54:00 | Metabolic profiling indicated increased energy expenditure in KCP-overexpressing mice and reduced expenditure in the KCP mutants with no effect on food intake or activity. These findings demonstrate that shifting the TGF-beta superfamily signaling with a secreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesity even when mice are fed a high-fat diet. | 28424263 |
| 2013-08-10 10:32:00 | These data suggest that extracellular regulation of the TGF-beta/BMP signaling axis by KCP, and by extension possibly other cysteine-rich domain proteins, can attenuate both acute and chronic renal injury. | 23539757 |
| 2010-01-21 00:00:00 | role for KCP in modulating the responses between these anti- and profibrotic cytokines in the initiation and progression of renal interstitial fibrosis | 16738323 |
| 2010-01-21 00:00:00 | The data indicate an important role for KCP in attenuating the pathology of renal fibrotic disease. | 15793581 |
| Type | IDs |
|---|---|
| Synonymous | AW060220, CRIM-2, Crim2, Gm793, KCP-1 |
| Gene |
UniProtKB-ID:
KCP_MOUSE
UniprotKB:
Q3U492
UniParc:
UPI000058BA7B,
UPI0001F794D8
EMBL:
AK154369,
AC079276,
AY884211
Ensembl:
ENSMUSG00000059022
KO:
mmu:333088
|
| Nucleutide sequences |
EMBL-CDS:
BAE32541.1,
AAX77677.1
Ensembl_TRS:
ENSMUST00000101614,
ENSMUST00000078112
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000077251,
ENSMUSP00000099135
RefSeq:
XP_011239373.1,
XP_017177152.1,
XP_006505194.1,
XP_011239372.1,
NP_001025156.3,
XP_017177150.1,
XP_017177149.1,
XP_006505197.1,
XP_030111349.1
|
| Others |
UniRef100:
UniRef100_Q3U492
UniRef90:
UniRef90_Q3U492
UniRef50:
UniRef50_Q3U492
UniGene:
Mm.332961
CCDS:
CCDS57415.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32913205 |
Transcriptional analysis of cleft palate in TGFβ3 mutant mice. Sci Rep J Liu , S K Chanumolu , K M White , M Albahrani , H H Otu , A Nawshad |
2020-09-10 | - |
| 32325033 |
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst Reza Pourhaghighi , Peter E A Ash , Sadhna Phanse , Florian Goebels , Lucas Z M Hu , Siwei Chen , Yingying Zhang , Shayne D Wierbowski , Samantha Boudeau , Mohamed T Moutaoufik , Ramy H Malty , Edyta Malolepsza , Kalliopi Tsafou , Aparna Nathan , Graham Cromar , Hongbo Guo , Ali Al Abdullatif , Daniel J Apicco , Lindsay A Becker , Aaron D Gitler , Stefan M Pulst , Ahmed Youssef , Ryan Hekman , Pierre C Havugimana , Carl A White , Benjamin C Blum , Antonia Ratti , Camron D Bryant , John Parkinson , Kasper Lage , Mohan Babu , Haiyuan Yu , Gary D Bader , Benjamin Wolozin , Andrew Emili |
2020-04-22 | - |
| 28424263 |
J Biol Chem Abdul Soofi , Katherine I Wolf , Margo P Emont , Nathan Qi , Gabriel Martinez-Santibanez , Edward Grimley , Wesam Ostwani , Gregory R Dressler |
2017-06-02 | - |
| 27514479 |
The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice. Am. J. Physiol. Gastrointest. Liver Physiol. Abdul Soofi , Katherine I Wolf , Egon J Ranghini , Mohammad A Amin , Gregory R Dressler |
2016-10-01 | - |
| 24029230 |
Cancer Cell Akiko Nagamachi , Hirotaka Matsui , Hiroya Asou , Yuko Ozaki , Daisuke Aki , Akinori Kanai , Keiyo Takubo , Toshio Suda , Takuro Nakamura , Linda Wolff , Hiroaki Honda , Toshiya Inaba |
2013-09-09 |
Gm13242,
Papd4,
Wdr7,
Ly76,
Pld4,
Ston2,
Krt75,
Slc8a3,
Vmn1r13,
Krtap5-5,
Cebpd,
Eef2,
Muc4,
Gsr,
Ptpn6,
Hoxb3,
Itgam,
Itgb3,
Kcnab2,
Lamp1,
Vmn1r214,
Pdgfra,
Pdgfrb,
Sirpa,
Ptprc,
Ptprz1,
Rbmy,
Rest,
Sin3a,
Serpinb9f,
Samd9l,
Dhtkd1,
Mmp21,
Eea1,
Thy1,
4930474N05Rik,
Arl11,
Top2a,
Prrc2c,
Ppp4r2,
Tcaf2,
Ptprq,
Bves,
Muc19,
Dact2,
Wdr78,
Siglecg,
Rbm47,
Zbtb24,
Rab5a,
Tmem91,
Abca15,
6330408A02Rik,
Dock1,
Kcp,
Mrgprx1,
Agpat5,
Arhgef7,
Vmn2r74,
Srsf4,
Tnfrsf13b,
Smpd3,
Rrs1,
Heatr9,
Zfp784,
Slc7a6os,
Gpatch4,
Acp6,
Herc6,
Dock7,
Narfl,
4930430F08Rik,
Eml1,
Hrnr,
Anln,
Cyp2c66,
Tmem143,
3830403N18Rik,
Col24a1,
Serpinb12,
Esco2,
Pygo1,
Ssbp3,
Sipa1l3,
Wdr38,
Armc6,
Tmem190,
Apobec3,
SAMD9,
EEA1
|
| 23539757 |
Kielin/chordin-like protein attenuates both acute and chronic renal injury. J. Am. Soc. Nephrol. Abdul Soofi , Peng Zhang , Gregory R Dressler |
2013-05-01 |
Kcp
|
| 17035289 |
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development Makoto Ikeya , Masako Kawada , Hiroshi Kiyonari , Noriaki Sasai , Kazuki Nakao , Yasuhide Furuta , Yoshiki Sasai |
2006-11-01 |
Acta2,
Acan,
Aqp5,
Bmp2,
Bmp4,
Bmp7,
Cdh1,
Col2a1,
Foxa2,
Isl1,
Ascl1,
Mki67,
Msx1,
Msx2,
Pax1,
Pax2,
Pax7,
Pecam1,
Sftpc,
Sox9,
Scgb1a1,
Wt1,
Zic1,
Kcp,
Bmper
|
| 16738323 |
Mol. Cell. Biol. Jingmei Lin , Sanjeevkumar R Patel , Min Wang , Gregory R Dressler |
2006-06-01 |
Kcp
|
| 16602821 |
PLoS Biol Susan Magdaleno , Patricia Jensen , Craig L Brumwell , Anna Seal , Karen Lehman , Andrew Asbury , Tony Cheung , Tommie Cornelius , Diana M Batten , Christopher Eden , Shannon M Norland , Dennis S Rice , Nilesh Dosooye , Sundeep Shakya , Perdeep Mehta , Tom Curran |
2006-04-01 | - |
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
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目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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{{author.size}} |
目前还没有研究热点人员