| Type | Description |
|---|---|
| Definition | smoothened |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 11:01:00 | Data show that hedgehog (Hh)-induced phosphorylation of signal transducer Smoothened (Smo) inhibits smurf E3 ligase (Smurf) recruitment to Smo. | 29438012 |
| 2019-09-21 10:55:00 | UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane. | 28992318 |
| 2019-04-27 11:15:00 | inactivation of the ESCRT-III causes dramatic accumulation of Smo in the ESCRT-III/MVB compartment, and subsequent activation of Hedgehog signaling | 29142103 |
| 2019-03-09 10:16:00 | This study observed an unexpected and significant Galphas -dependent increase in cAMP levels in response to strong Smo activation in Smo-transfected cells. | 30018136 |
| 2018-10-27 12:03:00 | A novel mechanism for Smo activation by sumoylation that is regulated by Hh and Smo interacting proteins is uncovered. | 28195188 |
| Type | IDs |
|---|---|
| Synonymous | CG11561, Dmel\CG11561, SMO, Smo, dSmo |
| Gene |
UniProtKB-ID:
SMO_DROME
UniprotKB:
P91682
UniParc:
UPI00001245E8
EMBL:
U87613,
AF030334,
AE014134,
BT053691
EnsemblGenome:
FBgn0003444
KO:
dme:Dmel_CG11561
|
| Nucleutide sequences |
EMBL-CDS:
ACK77608.1,
AAC33180.1,
AAB84275.1,
AAF51518.2
Gene_ORFName:
CG11561
EnsemblGenome_TRS:
FBtr0078129
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0077788
RefSeq:
NP_523443.1
|
| Others |
UniRef100:
UniRef100_P91682
UniRef90:
UniRef90_P91682
UniRef50:
UniRef50_P91682
UniGene:
Dm.244
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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