Hcn4 - hyperpolarization-activated, cyclic nucleotide-gated K+ 4-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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330953 Hcn4

基因描述

Type	Description
Definition	hyperpolarization-activated, cyclic nucleotide-gated K+ 4

研究结论

Date	Results	Publications
2021-01-23 12:56:00	Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome.	31751569
2020-11-28 13:17:00	cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells.	33144559
2020-05-09 11:32:00	Pdpk1 (PDK1) and AKT are involved in the regulation of HCN2 and HCN4 mRNA transcription, protein expression, HCN current density, and cell membrane location	32184125
2019-08-24 11:17:00	knockdown of HCN4 gave rise to sinus arrhythmia, and enhanced the parasympathetic response.	29315578
2019-03-23 11:43:00	HCN4 is expressed in various regions of the hippocampus. HCN4 knockdown produced no effect on contextual fear conditioning or spatial memory. Anxiogenic effect was evident in mice treated with short hairpin RNA against HCN4.	30585408

名称对应

Type	IDs
Synonymous	Bcng3, Hcn3
Gene	UniProtKB-ID: B2RY58_MOUSE UniprotKB: B2RY58 UniParc: UPI00001E44CA EMBL: BC158108, AC110530, BC158106 Ensembl: ENSMUSG00000032338 KO: mmu:330953
Nucleutide sequences	EMBL-CDS: AAI58109.1, AAI58107.1 Ensembl_TRS: ENSMUST00000034889
Protein sequencees	Ensembl_PRO: ENSMUSP00000034889 RefSeq: NP_001074661.1
Others	UniRef100: UniRef100_B2RY58 UniRef90: UniRef90_O70507 UniRef50: UniRef50_Q9Y3Q4 UniGene: Mm.151967

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
33443158	GATA6 is a regulator of sinus node development and heart rhythm. Proc Natl Acad Sci U S A Lara Gharibeh , Abir Yamak , Jamieson Whitcomb , Aizhu Lu , Mathieu Joyal , Hiba Komati , Wenbin Liang , CÃ©line Fiset , Mona Nemer	2021-01-05	-
33144559	cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells. Nat Commun Stefanie Fenske , Konstantin Hennis , RenÃ© D RÃ¶tzer , Verena F Brox , Elvir Becirovic , Andreas Scharr , Christian Gruner , Tilman Ziegler , Verena Mehlfeld , Jaclyn Brennan , Igor R Efimov , Audrys G PauÅ¾a , Markus Moser , Carsten T Wotjak , Christian Kupatt , Rasmus GÃ¶nner , Rai Zhang , Henggui Zhang , Xiangang Zong , Martin Biel , Christian Wahl-Schott	2020-11-03	-
32675240	T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. Proc Natl Acad Sci U S A Rajiv A Mohan , Fernanda M Bosada , Jan H van Weerd , Karel van Duijvenboden , Jianan Wang , Mathilda T M Mommersteeg , Ingeborg B Hooijkaas , Vincent Wakker , Corrie de Gier-de Vries , Ruben Coronel , Gerard J J Boink , Jeroen Bakkers , Phil Barnett , Bas J Boukens , Vincent M Christoffels	2020-08-04	-
32672536	Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction. Elife Jan Hendrik van Weerd , Rajiv A Mohan , Karel van Duijvenboden , Ingeborg B Hooijkaas , Vincent Wakker , Bastiaan J Boukens , Phil Barnett , Vincent M Christoffels	2020-07-16	-
32347164	ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res Wenli Dai , Rangarajan D Nadadur , Jaclyn A Brennan , Heather L Smith , Kaitlyn M Shen , Margaret Gadek , Brigitte Laforest , Mingyi Wang , Joanna Gemel , Ye Li , Jing Zhang , Bruce D Ziman , Jiajie Yan , Xun Ai , Eric C Beyer , Edward G Lakata , Narayanan Kasthuri , Igor R Efimov , Michael T Broman , Ivan P Moskowitz , Le Shen , Christopher R Weber	2020-07-03	-
32184125	PDK1-AKT signaling pathway regulates the expression and function of cardiac hyperpolarization-activated cyclic nucleotide-modulated channels. Life Sci. Zhonglin Han , Xiang Wu , Yuan Gao , Xuehua Liu , Jian Bai , Rong Gu , RongFang Lan , Biao Xu , Wei Xu	2020-06-01	-
31306714	Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression. Biochim Biophys Acta Mol Cell Res Vincent W W van Eif , Sonia Stefanovic , Rajiv A Mohan , Vincent M Christoffels	2020-03-01	-
31968244	Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development. Cell Rep Haruka Yamamoto , Tetsuo Kon , Yoshihiro Omori , Takahisa Furukawa	2020-01-21	-
32492036	A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure. PLoS One Heba Shawer , Esther Aiyelaagbe , Christopher Clowes , Samantha C Lean , Yinhui Lu , Karl E Kadler , Alan Kerby , Mark R Dilworth , Kathryn E Hentges , Alexander E P Heazell	2020-01-01	-
31751569	Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome. J Mol Cell Cardiol Bicheng Yang , Yanrui Huang , Haifeng Zhang , Yan Huang , Huanjiao Jenny Zhou , Lawrence Young , Haipeng Xiao , Wang Min	2020-01-01	-

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