| Type | Description |
|---|---|
| Definition | collagen, type VIII, alpha 2 |
| Date | Results | Publications |
|---|---|---|
| 2013-05-25 10:31:00 | Overexpression of the Col8a2 gene in mouse and human Fuchs endothelial corneal dystrophy endothelial cells suggested a role for altered autophagy in this disease. | 23422828 |
| 2012-11-24 10:13:00 | in contrast to diabetic wild-type mice EMT-like changes were attenuated in diabetic Col8alpha1/alpha2-KO mice, indicating that collagen VIII may be 1 of the major inducers of epithelial-to-mesenchymal transition-like changes in kidneys of diabetic wild-type mice | 22759394 |
| 2012-04-28 10:50:00 | study confirms the Q455K substitution in the COL8A2 gene as being sufficient to cause FECD in the first mouse model of this disease and supports the role of the UPR and UPR-associated apoptosis in the pathogenesis of FECD caused by COL8A2 mutations | 22002996 |
| 2011-05-28 11:00:00 | Type VIII collagen significantly modulates the effect of TGF-beta1 on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy. | 21372207 |
| 2010-01-21 00:00:00 | Lack of type VIII collagen confers renoprotection in diabetic nephropathy in a knockout mouse model. | 19401424 |
| Type | IDs |
|---|---|
| Synonymous | AI429819 |
| Gene |
UniProtKB-ID:
CO8A2_MOUSE
UniprotKB:
P25318
UniParc:
UPI0000232A16,
UPI0000419FEC
EMBL:
AK131153,
BC065148,
BC080317,
AL606976,
M60833
Ensembl:
ENSMUSG00000056174
KO:
mmu:329941
|
| Nucleutide sequences |
EMBL-CDS:
BAD21403.1,
AAH65148.1,
AAH80317.1
Ensembl_TRS:
ENSMUST00000070132
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000070270
RefSeq:
NP_955767.1,
XP_017175755.1
|
| Others |
UniRef100:
UniRef100_P25318
UniRef90:
UniRef90_P25318
UniRef50:
UniRef50_P25067
UniGene:
Mm.296327
CCDS:
CCDS18649.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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