| Type | Description |
|---|---|
| Definition | Fras1 related extracellular matrix protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2014-06-21 10:18:00 | loss of FREM1 function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC activity, in addition to its stabilising role in the basement membrane | 24046351 |
| 2013-12-28 10:40:00 | FREM1-deficient mice faithfully recapitulate many of the phenotypes seen in individuals with FREM1 deficiency and that variations in GATA4 and SLIT3 expression modulate some FREM1-related phenotypes in mice. | 23536828 |
| 2013-07-27 10:52:00 | We conclude that FREM1 plays a critical role in the development of the diaphragm and that FREM1 deficiency can cause CDH in both humans and mice. | 23221805 |
| 2012-08-25 10:45:00 | the loss of QBRICK significantly diminished The expression of nephronectin, an integrin alpha8beta1 ligand necessary for renal development. | 22613833 |
| 2012-01-28 11:49:00 | Frem1 mutant mice is the first bona fide mouse model of human metopic craniosynostosis and a new model for midfacial hypoplasia. | 21931569 |
| Type | IDs |
|---|---|
| Synonymous |
BC037594,
D430009N09,
D630008K06,
crf11,
eye |
| Gene |
UniProtKB-ID:
FREM1_MOUSE,
A2ADN1_MOUSE
UniprotKB:
Q684R7,
A2ADN1
UniParc:
UPI00004C7029,
UPI000042B0E6,
UPI000057680E
EMBL:
AB160986,
BC088732,
BC138427,
AJ616838,
AK052629
Ensembl:
ENSMUSG00000059049
KO:
mmu:329872
|
| Nucleutide sequences |
EMBL-CDS:
CAE83577.1,
AAH88732.1,
BAC35069.1,
BAD89014.1,
AAI38428.1
Ensembl_TRS:
ENSMUST00000107230,
ENSMUST00000071708
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000102849,
ENSMUSP00000071627
RefSeq:
XP_011248357.1,
XP_006538081.1,
XP_030109476.1,
XP_006538077.1,
XP_006538078.1,
XP_036020085.1,
XP_006538076.1,
NP_808531.2,
XP_036020084.1,
NP_001185740.1
|
| Others |
UniRef100:
UniRef100_Q684R7,
UniRef100_A2ADN1
UniRef90:
UniRef90_Q684R7
UniRef50:
UniRef50_Q684R7
UniGene:
Mm.242337
CCDS:
CCDS38791.1,
CCDS57281.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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