| Type | Description |
|---|---|
| Definition | Merlin |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 12:17:00 | Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibromatosis 2, is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (CySCs) in the Drosophila testis. | 28566755 |
| 2017-06-24 12:44:00 | Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex. | 28292426 |
| 2017-05-27 11:12:00 | Rae1 increases activation of the core kinases Hippo and Warts and plays a post-transcriptional role to increase the protein levels of the Merlin, Hippo, and Warts components of the pathway; therefore, in addition to Rae1 coordinating organ size regulation with proliferative control, we propose that Rae1 also acts in a feedback circuit to regulate pathway homeostas | 27494403 |
| 2015-07-25 11:32:00 | Sip1 facilitates the activation of Merlin as a tumor suppressor protein. | 25204795 |
| 2013-11-30 11:59:00 | These results indicate that in both Drosophila and mammals, Merlin activates Wts/Lats phosphorylation without stimulating the intrinsic kinase activity of Hpo/Mst. | 24012335 |
| Type | IDs |
|---|---|
| Synonymous | BG01543, CG14228, D-Mer, Dmel\CG14228, Dmerlin, EMR2, Emr2, NF2, mer |
| Gene |
UniProtKB-ID:
MERH_DROME,
X2JFU0_DROME
UniprotKB:
Q24564,
X2JFU0
UniParc:
UPI000007F16C
EMBL:
U23799,
AY094998,
U49724,
AE014298
EnsemblGenome:
FBgn0086384
KO:
dme:Dmel_CG14228
|
| Nucleutide sequences |
EMBL-CDS:
AAA65060.1,
AAF49005.1,
AAM11326.1,
AAB08449.1,
AHN59928.1
Gene_ORFName:
CG14228,
Dmel_CG14228,
CG14228
EnsemblGenome_TRS:
FBtr0074754,
FBtr0345992,
FBtr0074754,
FBtr0345992
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0311877,
FBpp0074523,
FBpp0311877,
FBpp0074523
RefSeq:
NP_523413.1,
NP_001285458.1
|
| Others |
UniRef100:
UniRef100_Q24564
UniRef90:
UniRef90_Q24564
UniRef50:
UniRef50_Q24564
UniGene:
Dm.2765
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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