| Type | Description |
|---|---|
| Definition | fibroblast growth factor receptor substrate 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-15 19:05:00 | FRS2alpha-dependent cell fate transition during endocardial cushion morphogenesis. | 31669335 |
| 2019-02-23 13:31:00 | FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS2&3 promote dentate gyrus morphogenesis and dentate granule cell (DGC) maturation during developmental neurogenesis. Frs2,3-double mutants have reduced numbers of dendritic branches and spines in DGCs. Double-mutant mice exhibit fewer excitatory synaptic inputs onto DGCs. | 29155277 |
| 2018-08-06 16:44:00 | FRS2alpha-mediated pathways are essential for the FGF15/FGF19-FGFR4 signaling axis to control bile acid homeostasis. | 25056539 |
| 2018-07-14 10:03:00 | controlsConclusionFrs2alpha(ST-/-) embryos have aberrant ureteric induction sites, improper ureteral insertion, shortened intravesicular lengths, and VUR | 29135976 |
| 2018-07-07 12:25:00 | Embryonic day 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants had proximal tubular-derived cysts that nearly replaced the renal parenchyma by P21. Mutants had high proximal tubular proliferation rates and interstitial fibrosis, similar to known polycystic kidney disease models. | 27853247 |
| Type | IDs |
|---|---|
| Synonymous | 4732458E18, C330018A15Rik, Frs2alpha, SNT1 |
| Gene |
UniProtKB-ID:
FRS2_MOUSE
UniprotKB:
Q8C180
UniParc:
UPI000000B2FF
EMBL:
BC055334,
AK028813,
BC043109
Ensembl:
ENSMUSG00000020170
KO:
mmu:327826
|
| Nucleutide sequences |
EMBL-CDS:
BAC26132.1,
AAH55334.1,
AAH43109.1
Ensembl_TRS:
ENSMUST00000020381
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000020381
RefSeq:
XP_036011747.1,
XP_036011746.1,
NP_808466.1,
XP_036011748.1,
XP_036011744.1,
XP_036011749.1,
XP_036011745.1
|
| Others |
UniRef100:
UniRef100_Q8C180
UniRef90:
UniRef90_Q8C180
UniRef50:
UniRef50_Q8C180
UniGene:
Mm.135965
CCDS:
CCDS24190.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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