| Type | Description |
|---|---|
| Definition | minibrain |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 11:32:00 | This study demonstrated that neuronal overexpression of mnb, the Drosophila ortholog of DYRK1A, is sufficient to induce motor impairment, accelerate age-related decline in motor performance, shorten lifespan and cause age-dependent neurodegeneration | 30703437 |
| 2019-10-05 11:06:00 | We propose that Mnb/Dyrk1A plays a central role in central nervous system neurogenesis by integrating molecular mechanisms that regulate progenitor self-renewal, cell cycle progression and neuronal differentiation | 29495936 |
| 2018-01-27 11:42:00 | We have thus uncovered a previously unknown mechanism of down-regulation of Cic activity by Mnb and Wap, which operates independently from the ERK-mediated control of Cic. Therefore, Cic functions as an integrator of upstream signals that are essential for tissue patterning and organ growth | 27601662 |
| 2017-08-26 13:10:00 | results demonstrate that phosphoregulation of microtubule dynamics by MNB/DYRK1a is critical for dendritic patterning and neuronal function | 27112495 |
| 2015-10-31 10:23:00 | Mnb is a synaptic kinase that promotes efficient synaptic vesicle recycling by Synj function at the neuromuscular junction. | 24977345 |
| Type | IDs |
|---|---|
| Synonymous | CG42273, CG7826, CG7835, DYRK1, Dm1, DmDyrk1A, Dmel\CG42273, Dmel_CG7826, Dmel_CG7835, Dyrk1, Dyrk1A, ME-IV, MNB, Mnb, min |
| Gene |
UniProtKB-ID:
MNB_DROME,
Q9VX06_DROME,
X2JFM3_DROME
UniprotKB:
P49657,
Q9VX06,
X2JFM3
UniParc:
UPI00004C5A8E,
UPI00000784A7,
UPI00000072DB,
UPI00001E2BE6,
UPI0001914A67
EMBL:
X70794,
X70799,
AE014298,
X70798,
BT015255
EnsemblGenome:
FBgn0259168
KO:
dme:Dmel_CG42273
|
| Nucleutide sequences |
EMBL-CDS:
AAF48777.3,
AAT94484.1,
AAN09442.1,
AAX52504.1,
CAA50068.1,
CAA50065.1,
CAA50069.1,
AAF48778.2,
AHN59863.1
Gene_ORFName:
CG7826,
CG42273,
Dmel_CG42273,
Dmel_CG42273,
CG42273
EnsemblGenome_TRS:
FBtr0299619,
FBtr0300509,
FBtr0300508,
FBtr0300510,
FBtr0342786
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0289736,
FBpp0288894,
FBpp0289735,
FBpp0289737,
FBpp0309627
RefSeq:
NP_728104.1,
NP_001014750.1,
NP_728106.1,
NP_728107.2,
NP_001285393.1
|
| Others |
UniRef100:
UniRef100_X2JFM3,
UniRef100_P49657,
UniRef100_Q9VX06
UniRef90:
UniRef90_P49657,
UniRef90_P49657-3
UniRef50:
UniRef50_P49657,
UniRef50_P49657-3
UniGene:
Dm.3606
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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