| Type | Description |
|---|---|
| Definition | neurofibromin 1a |
| Date | Results | Publications |
|---|---|---|
| 2017-10-21 11:20:00 | The authors demonstrate in zebrafish that nf1 loss leads to aberrant activation of RAS signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma in nf1-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 mutant embryos. | 27130733 |
| 2011-05-14 10:47:00 | study shows negative regulation of Ras pathway through GAP activity of NF1 limits oligodendrocyte progenitor cell (OPC) proliferation and motility during development; provides insight into oncogenic mechanisms by which NF1 loss contributes to glial tumors | 20858602 |
| 2010-04-19 02:17:00 | identification and characterization of nf1a and nf1b, orthologues of NF1, that show neural crest and cardiovascular defects resulting from morpholino knockdown, including vascular and cardiac valvular abnormalities | 19966217 |
| Type | IDs |
|---|---|
| Synonymous | fe06d03, hm:zehn0874, nf1, wu:fe06d03, zehn0874 |
| Gene | |
| Nucleutide sequences | |
| Protein sequencees |
RefSeq:
XP_009290039.1,
XP_021322125.1,
XP_021322121.1,
XP_021322120.1,
XP_009290044.1,
XP_021322122.1,
XP_021322123.1,
XP_021322124.1
|
| Others |
UniGene:
Dr.105499,
Dr.122240
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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