| Type | Description |
|---|---|
| Definition | UPF2 regulator of nonsense transcripts homolog (yeast) |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 10:44:00 | our findings indicate that impaired UPF2-dependent nonsense-mediated decay leads to neurodevelopmental dysfunction | 31585809 |
| 2017-05-13 12:39:00 | we report that UPF2-mediated nonsense-mediated mRNA decay (NMD) plays an essential role in male germ cells by eliminating ubiquitous genes-derived, longer 3'UTR transcripts, and that this role is independent of its canonical role in degrading "premature termination codon" (PTC)-containing transcripts in somatic cell lineages | 27149259 |
| 2017-05-13 12:39:00 | Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies . | 27149095 |
| 2015-03-21 13:02:00 | UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. | 25503407 |
| 2010-10-30 11:14:00 | Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis. | 20657840 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
RENT2_MOUSE
UniprotKB:
A2AT37
UniParc:
UPI00001E3048
EMBL:
CR388026,
BC138359,
AL928735,
BC138358,
AL928924
Ensembl:
ENSMUSG00000043241
KO:
mmu:326622
|
| Nucleutide sequences |
EMBL-CDS:
AAI38360.1,
AAI38359.1
Ensembl_TRS:
ENSMUST00000060092
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000058375
RefSeq:
XP_006497548.1,
NP_001074601.1,
XP_006497549.1,
XP_006497551.1,
XP_006497550.1
|
| Others |
UniRef100:
UniRef100_A2AT37
UniRef90:
UniRef90_Q9HAU5
UniRef50:
UniRef50_Q9HAU5
UniGene:
Mm.31102
CCDS:
CCDS38041.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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